Theranostics 2020; 10(23):10652-10664. doi:10.7150/thno.47933 This issue Cite

Research Paper

3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer

Xuelei Shi1,2*, Yanxiang Cheng3*, Jian Wang1,2, Haoxiang Chen1,2, Xiaocheng Wang1, Xinghuan Li1, Weihong Tan1, Zhikai Tan1,2✉

1. College of Biology, Hunan University, Changsha, Hunan, 410082, China.
2. Shenzhen Institute, Hunan University, Shenzhen, Guangdong, 518000, China.
3. Department of Obstetrics and Gynecology, Renmin Hospital, Wuhan University, Wuhan, Hubei, 430060, China.
*These authors contributed equally to this work.

Citation:
Shi X, Cheng Y, Wang J, Chen H, Wang X, Li X, Tan W, Tan Z. 3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer. Theranostics 2020; 10(23):10652-10664. doi:10.7150/thno.47933. https://www.thno.org/v10p10652.htm
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Abstract

Graphic abstract

Rationale: Tumors are commonly treated by resection, which usually leads to massive hemorrhage and tumor cell residues, thereby increasing the risk of local recurrence and distant metastasis.

Methods: Herein, an intelligent 3D-printed poly(lactic-co-glycolic acid), gelatin, and chitosan scaffold loaded with anti-cancer drugs was prepared that showed hemostatic function and good pH sensitivity.

Results: Following in situ implantation in wounds, the scaffolds absorbed hemorrhage and cell residues after surgery, and promoted wound healing. In an in vivo environment, the scaffold responded to the slightly acidic environment of the tumor to undergo sustained drug release to significantly inhibit the recurrence and growth of the tumor, and reduced drug toxicity, all without causing damage to healthy tissues and with good biocompatibility.

Conclusions: The multifunctional intelligent scaffold represents an excellent treatment modality for breast cancer following resection, and provides great potential for efficient cancer therapy.

Keywords: Biofabrication, Environment response, Hemostasis, Prevention of tumor recurrence, Wound healing


Citation styles

APA
Shi, X., Cheng, Y., Wang, J., Chen, H., Wang, X., Li, X., Tan, W., Tan, Z. (2020). 3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer. Theranostics, 10(23), 10652-10664. https://doi.org/10.7150/thno.47933.

ACS
Shi, X.; Cheng, Y.; Wang, J.; Chen, H.; Wang, X.; Li, X.; Tan, W.; Tan, Z. 3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer. Theranostics 2020, 10 (23), 10652-10664. DOI: 10.7150/thno.47933.

NLM
Shi X, Cheng Y, Wang J, Chen H, Wang X, Li X, Tan W, Tan Z. 3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer. Theranostics 2020; 10(23):10652-10664. doi:10.7150/thno.47933. https://www.thno.org/v10p10652.htm

CSE
Shi X, Cheng Y, Wang J, Chen H, Wang X, Li X, Tan W, Tan Z. 2020. 3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer. Theranostics. 10(23):10652-10664.

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