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Volume 10 (23); 2020

Research Papers

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Bladder reconstruction using autologous smooth muscle cell sheets grafted on a pre-vascularized capsule
Hai-Lin Guo, Xu-Feng Peng, Xing-Qi Bao, Lin Wang, Zhi-Ming Jia, Yi-Chen Huang, Jun-Mei Zhou, Hua Xie, Fang Chen
Theranostics 2020; 10(23): 10378-10393. doi:10.7150/thno.47006
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Recognition of G-quadruplex topology through hybrid binding with implications in cancer theranostics
Yelisetty Venkata Suseela, Pardhasaradhi Satha, N. Arul Murugan, Thimmaiah Govindaraju
Theranostics 2020; 10(23): 10394-10414. doi:10.7150/thno.48675
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Statins ameliorate cholesterol-induced inflammation and improve AQP2 expression by inhibiting NLRP3 activation in the kidney
Yonglun Kong, Weijing Feng, Xiaoduo Zhao, Puhua Zhang, Suchun Li, Zhijian Li, Yu Lin, Boen Liang, Chunling Li, Weidong Wang, Hui Huang
Theranostics 2020; 10(23): 10415-10433. doi:10.7150/thno.49603
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma
Xuejing Zou, Dongyan Zhang, Yang Song, Shanshan Liu, Qian Long, Liheng Yao, Wenwen Li, Zhijiao Duan, Dehua Wu, Li Liu
Theranostics 2020; 10(23): 10434-10447. doi:10.7150/thno.47286
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Opto-acoustic synergistic irradiation for vaporization of natural melanin-cored nanodroplets at safe energy levels and efficient sono-chemo-photothermal cancer therapy
Yaxin Hu, Shan Xue, Ting Long, Peizhao Lyu, Xinyu Zhang, Jingqin Chen, Siping Chen, Chengbo Liu, Xin Chen
Theranostics 2020; 10(23): 10448-10465. doi:10.7150/thno.44879
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dihydroartemisinin ameliorates psoriatic skin inflammation and its relapse by diminishing CD8+ T-cell memory in wild-type and humanized mice
Yuchao Chen, Yuhong Yan, Huazhen Liu, Feifei Qiu, Chun-Ling Liang, Qunfang Zhang, Run-Yue Huang, Ling Han, Chuanjian Lu, Zhenhua Dai
Theranostics 2020; 10(23): 10466-10482. doi:10.7150/thno.45211
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir-/- murine psoriasis
Chenxin Qie, Jingwei Jiang, Wanmei Liu, Xinlei Hu, Wenting Chen, Xiaoxue Xie, Jun Liu
Theranostics 2020; 10(23): 10483-10497. doi:10.7150/thno.45614
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Combination therapy with B7H3-redirected bispecific antibody and Sorafenib elicits enhanced synergistic antitumor efficacy
Cheng Huang, Hongjian Li, Yunyu Feng, Xiaoling Li, Zongliang Zhang, Caiying Jiang, Jichao Wang, Chenli Yang, Yuying Fu, Min Mu, Shasha Zhao, Zeng Wang, Yi Kuang, Huan Hou, Yuelong Wang, Wenhao Guo, Jianguo Xu, Hui Yang, Liangxue Zhou, Aiping Tong, Gang Guo
Theranostics 2020; 10(23): 10498-10512. doi:10.7150/thno.49480
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy
Xiaoyu Xu, Binyao Huang, Zishan Zeng, Jie Chen, Zeqian Huang, Zilin Guan, Meixu Chen, Yanjuan Huang, Chunshun Zhao
Theranostics 2020; 10(23): 10513-10530. doi:10.7150/thno.49731
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dissecting the heterogeneity of the alternative polyadenylation profiles in triple-negative breast cancers
Lei Wang, Guan-Tian Lang, Meng-Zhu Xue, Liu Yang, Li Chen, Ling Yao, Xiao-Guang Li, Peng Wang, Xin Hu, Zhi-Ming Shao
Theranostics 2020; 10(23): 10531-10547. doi:10.7150/thno.40944
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications
Alexandra Marie Mowday, Janine Naomi Copp, Sophie Philippa Syddall, Ludwig Jerome Dubois, Jingli Wang, Natasja Gabi Lieuwes, Rianne Biemans, Amir Ashoorzadeh, Maria Rosaria Abbattista, Elsie May Williams, Christopher Paul Guise, Philippe Lambin, David Francis Ackerley, Jeff Bruce Smaill, Jan Theys, Adam Vorn Patterson
Theranostics 2020; 10(23): 10548-10562. doi:10.7150/thno.46826
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Association of sex and APOE ε4 with brain tau deposition and atrophy in older adults with Alzheimer's disease
Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Jian Li, Tammie L.S. Benzinger, Jie Lu, Yun Zhou
Theranostics 2020; 10(23): 10563-10572. doi:10.7150/thno.48522
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cadherin-11 cooperates with inflammatory factors to promote the migration and invasion of fibroblast-like synoviocytes in pigmented villonodular synovitis
Chenxi Cao, Fei Wu, Xingyue Niu, Xiaoqing Hu, Jin Cheng, Yan Zhang, Chuanyun Li, Xiaoning Duan, Xin Fu, Jiying Zhang, Xin Zhang, Yingfang Ao
Theranostics 2020; 10(23): 10573-10588. doi:10.7150/thno.48666
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy
Shuli Liu, Yang Wang, Yong Han, Weiya Xia, Ling Zhang, Shengming Xu, Houyu Ju, Xiangkai Zhang, Guoxin Ren, Liu Liu, Weimin Ye, Zhiyuan Zhang, Jingzhou Hu
Theranostics 2020; 10(23): 10589-10605. doi:10.7150/thno.47176
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification of second primary tumors from lung metastases in patients with esophageal squamous cell carcinoma using whole-exome sequencing
Liyan Xue, Weihua Li, Xinyi Fan, Zitong Zhao, Wei Zhou, Zhimin Feng, Linxiu Liu, Hua Lin, Lin Li, Xuemin Xue, Xuanlin Huang, Peide Huang, Jia Guo, Peina Du, Ning Lu, Lin Li, Qimin Zhan, Yongmei Song
Theranostics 2020; 10(23): 10606-10618. doi:10.7150/thno.45311
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner
Qian-Feng Zhang, Jia Li, Kuo Jiang, Rui Wang, Jun-li Ge, Hong Yang, Shu-Juan Liu, Lin-Tao Jia, Lei Wang, Bi-Liang Chen
Theranostics 2020; 10(23): 10619-10633. doi:10.7150/thno.44871
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Methylation-mediated LINC00261 suppresses pancreatic cancer progression by epigenetically inhibiting c-Myc transcription
Songsong Liu, Yao Zheng, Yujun Zhang, Junfeng Zhang, Fuming Xie, Shixiang Guo, Jianyou Gu, Jiali Yang, Ping Zheng, Jiejuan Lai, Liangyu Yin, Huaizhi Wang
Theranostics 2020; 10(23): 10634-10651. doi:10.7150/thno.44278
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer
Xuelei Shi, Yanxiang Cheng, Jian Wang, Haoxiang Chen, Xiaocheng Wang, Xinghuan Li, Weihong Tan, Zhikai Tan
Theranostics 2020; 10(23): 10652-10664. doi:10.7150/thno.47933
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis
Jiawei Wu, Zhonghong Wei, Peng Cheng, Cheng Qian, Fangming Xu, Yu Yang, Aiyun Wang, Wenxing Chen, Zhiguang Sun, Yin Lu
Theranostics 2020; 10(23): 10665-10679. doi:10.7150/thno.43528
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion
Dongcheng Feng, Zhecheng Wang, Yan Zhao, Yang Li, Deshun Liu, Zhao Chen, Shili Ning, Yan Hu, Jihong Yao, Xiaofeng Tian
Theranostics 2020; 10(23): 10680-10696. doi:10.7150/thno.44250
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Melatonin overcomes MCR-mediated colistin resistance in Gram-negative pathogens
Yuan Liu, Yuqian Jia, Kangni Yang, Ziwen Tong, Jingru Shi, Ruichao Li, Xia Xiao, Wenkai Ren, Rüdiger Hardeland, Russel J. Reiter, Zhiqiang Wang
Theranostics 2020; 10(23): 10697-10711. doi:10.7150/thno.45951
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation
Wenhua Yan, Tianhan Li, Tieying Yin, Zhengjun Hou, Kai Qu, Nan Wang, Colm Durkan, Lingqing Dong, Juhui Qiu, Hans Gregersen, Guixue Wang
Theranostics 2020; 10(23): 10712-10728. doi:10.7150/thno.46143
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The ERα-miR-575-p27 feedback loop regulates tamoxifen sensitivity in ER-positive Breast Cancer
Shu-Shu Liu, Yun Li, Hui Zhang, Di Zhang, Xiao-Bei Zhang, Xin Wang, Yue Yu
Theranostics 2020; 10(23): 10729-10742. doi:10.7150/thno.46297
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis
Qi Zhang, Cheng Cao, Wenchen Gong, Kaiwen Bao, Qian Wang, Yuejiao Wang, Liyuan Bi, Shuai Ma, Jiao Zhao, Ling Liu, Shanshan Tian, Kai Zhang, Jie Yang, Zhi Yao, Nan Song, Lei Shi
Theranostics 2020; 10(23): 10769-10790. doi:10.7150/thno.46878
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis
Huan Liu, Guanghui Hu, Zaoyu Wang, Qunlong Liu, Jin Zhang, Yonghui Chen, Yiran Huang, Wei Xue, Yunfei Xu, Wei Zhai
Theranostics 2020; 10(23): 10791-10807. doi:10.7150/thno.47239
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Oral delivery of anti-TNF antibody shielded by natural polyphenol-mediated supramolecular assembly for inflammatory bowel disease therapy
Xinyu Wang, Junjie Yan, Lizhen Wang, Donghui Pan, Yuping Xu, Fang Wang, Jie Sheng, Xinxin Li, Min Yang
Theranostics 2020; 10(23): 10808-10822. doi:10.7150/thno.47601
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LncRNA DSCAM-AS1 interacts with YBX1 to promote cancer progression by forming a positive feedback loop that activates FOXA1 transcription network
Yin Zhang, Yong-Xin Huang, Dan-Lan Wang, Bing Yang, Hai-Yan Yan, Le-Hang Lin, Yun Li, Jie Chen, Li-Min Xie, Yong-Sheng Huang, Jian-You Liao, Kai-Shun Hu, Jie-Hua He, Phei Er Saw, Xiaoding Xu, Dong Yin
Theranostics 2020; 10(23): 10823-10837. doi:10.7150/thno.47830
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor immune profiles noninvasively estimated by FDG PET with deep learning correlate with immunotherapy response in lung adenocarcinoma
Changhee Park, Kwon Joong Na, Hongyoon Choi, Chan-Young Ock, Seunggyun Ha, Miso Kim, Samina Park, Bhumsuk Keam, Tae Min Kim, Jin Chul Paeng, In Kyu Park, Chang Hyun Kang, Dong-Wan Kim, Gi-Jeong Cheon, Keon Wook Kang, Young Tae Kim, Dae Seog Heo
Theranostics 2020; 10(23): 10838-10848. doi:10.7150/thno.50283
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Managing therapeutic resistance in breast cancer: from the lncRNAs perspective
Liyuan Peng, Jingwen Jiang, Bo Tang, Edouard C. Nice, Yuan-Yuan Zhang, Na Xie
Theranostics 2020; 10(23): 10360-10377. doi:10.7150/thno.49922
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts
Peter Valent, Cem Akin, Karin Hartmann, Gunnar Nilsson, Andreas Reiter, Olivier Hermine, Karl Sotlar, Wolfgang R. Sperr, Luis Escribano, Tracy I. George, Hanneke C. Kluin-Nelemans, Celalettin Ustun, Massimo Triggiani, Knut Brockow, Jason Gotlib, Alberto Orfao, Petri T. Kovanen, Emir Hadzijusufovic, Irina Sadovnik, Hans-Peter Horny, Michel Arock, Lawrence B. Schwartz, K. Frank Austen, Dean D. Metcalfe, Stephen J. Galli
Theranostics 2020; 10(23): 10743-10768. doi:10.7150/thno.46719
[Abstract] [Full text] [PDF] [PubMed] [PMC]