Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

Yao, Qing; Lan, Qing-Hua; Jiang, Xinyu; Du, Chu-Chu; Zhai, Yuan-Yuan; Shen, Xiaohan; Xu, He-Lin; Xiao, Jian; Kou, Longfa; Zhao, Ying-Zheng

doi:10.7150/thno.47682

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Nanotheranostics 2024; 8(3): 380-400. [Abstract] [Full text] [PDF]

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Theranostics 2020; 10(25):11719-11736. doi:10.7150/thno.47682 This issue Cite

Research Paper

Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

Qing Yao^1,2,#, Qing-Hua Lan^2,#, Xinyu Jiang³, Chu-Chu Du², Yuan-Yuan Zhai², Xiaohan Shen⁴, He-Lin Xu², Jian Xiao², Longfa Kou^3,✉, Ying-Zheng Zhao^1,2✉

1. Department of Ultrasonography, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
3. Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325035, China
4. Department of Oncology, Affiliated Cixi Hospital, Wenzhou Medical University, Cixi, 315300, China.
^#These authors contributed equally to this work.

Citation:

Yao Q, Lan QH, Jiang X, Du CC, Zhai YY, Shen X, Xu HL, Xiao J, Kou L, Zhao YZ. Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing. Theranostics 2020; 10(25):11719-11736. doi:10.7150/thno.47682. https://www.thno.org/v10p11719.htm

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Abstract

Rationale: Photothermal therapy employs the photoabsorbers to generate heat under the near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might damage the adjacent tissue due to the leakage of the photoabsorbers and the residual materials after treatment might hinder the local healing process. A bifunctional hydrogel that holds both photothermal property and potent pro-healing ability provides a viable option to resolve this issue.

Methods: In this study, we developed a bioinspired green hydrogel (BVSF) with the integration of bioproduct biliverdin into natural derived silk fibroin matrix for antiglioma photothermal therapy and wound healing.

Results: The BVSF hydrogel possessed excellent and controllable photothermal activity under NIR irradiation and resulted in effective tumor ablation both in vitro and in vivo. Additionally, the BVSF hydrogel exerted anti-inflammatory effects both in vitro and in vivo, and stimulated angiogenesis and wound healing in a full-thickness defect rat model.

Conclusion: Overall, this proof-of-concept study was aimed to determine the feasibility and reliability of using an all-natural green formulation for photothermal therapy and post-treatment care.

Keywords: biliverdin, silk fibroin, hydrogel, photothermal therapy, wound healing

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APA

Yao, Q., Lan, Q.H., Jiang, X., Du, C.C., Zhai, Y.Y., Shen, X., Xu, H.L., Xiao, J., Kou, L., Zhao, Y.Z. (2020). Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing. Theranostics, 10(25), 11719-11736. https://doi.org/10.7150/thno.47682.

ACS

Yao, Q.; Lan, Q.H.; Jiang, X.; Du, C.C.; Zhai, Y.Y.; Shen, X.; Xu, H.L.; Xiao, J.; Kou, L.; Zhao, Y.Z. Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing. Theranostics 2020, 10 (25), 11719-11736. DOI: 10.7150/thno.47682.

NLM

CSE

Yao Q, Lan QH, Jiang X, Du CC, Zhai YY, Shen X, Xu HL, Xiao J, Kou L, Zhao YZ. 2020. Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing. Theranostics. 10(25):11719-11736.

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