Theranostics 2020; 10(5):2273-2283. doi:10.7150/thno.38501 This issue

Research Paper

68Ga-PSMA-HBED-CC PET/CT imaging for adenoid cystic carcinoma and salivary duct carcinoma: a phase 2 imaging study

Wim van Boxtel1, Susanne Lütje2,3, Ilse C.H. van Engen-van Grunsven4, Gerald W. Verhaegh5, Jack A. Schalken5, Marianne A. Jonker6, James Nagarajah2,7, Martin Gotthardt2, Carla M.L. van Herpen1✉

1. Department of Medical Oncology, Radboud university medical center, Nijmegen, the Netherlands
2. Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, the Netherlands
3. Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany
4. Department of Pathology, Radboud university medical center, Nijmegen, the Netherlands
5. Department of Urology, Radboud university medical center, Nijmegen, the Netherlands
6. Department of Health Evidence, Radboud university medical center, Nijmegen, the Netherlands
7. Department of Nuclear Medicine, Technical University Munich, Germany

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Citation:
van Boxtel W, Lütje S, van Engen-van Grunsven ICH, Verhaegh GW, Schalken JA, Jonker MA, Nagarajah J, Gotthardt M, van Herpen CML. 68Ga-PSMA-HBED-CC PET/CT imaging for adenoid cystic carcinoma and salivary duct carcinoma: a phase 2 imaging study. Theranostics 2020; 10(5):2273-2283. doi:10.7150/thno.38501. Available from https://www.thno.org/v10p2273.htm

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Abstract

Graphic abstract

Rationale: Treatment options for recurrent and/or metastatic (R/M) adenoid cystic carcinoma (ACC) and salivary duct carcinoma (SDC), major subtypes of salivary gland cancer, are limited. Both tumors often show overexpression of prostate-specific membrane antigen (PSMA). In prostate cancer, PSMA-ligands labeled with 68Ga or 177Lu are used for imaging and therapy, respectively. Primary aim of this study in R/M ACC and SDC patients was to systematically investigate 68Ga-PSMA-uptake by PET/CT imaging to determine if PSMA radionuclide therapy could be a treatment option.

Methods: In a prospective phase II study, PET/CT imaging was performed 1 h post injection of 68Ga-PSMA-HBED-CC in 15 ACC patients and 10 SDC patients. Maximum standardized uptake values (SUV) were determined in tumor lesions. Immunohistochemical PSMA expression was scored in primary tumors and metastatic tissue. Standard imaging (MRI or CT) was performed for comparison.

Results: In ACC patients, SUVmax ranged from 1.1 to 30.2 with a tumor/liver-ratio >1 in 13 out of 14 evaluable patients (93%). In SDC patients, SUVmax ranged from 0.3 to 25.9 with a tumor/liver-ratio >1 in 4 out of 10 patients (40%). We found a large intra-patient inter-metastatic variation in uptake of 68Ga-PSMA, and immunohistochemistry did not predict ligand uptake in ACC and SDC. Finally, PSMA-PET detected additional bone metastases compared to CT in 2 ACC patients with unexplained pain.

Conclusion: In 93% of ACC patients and 40% of SDC patients we detected relevant PSMA-ligand uptake, which warrants to study PSMA radionuclide therapy in these patients. Additionally, our data provide arguments for patient selection and treatment timing. Finally, PSMA-PET imaging has added diagnostic value compared to CT in selected patients.

Keywords: Prostate-specific membrane antigen, Positron-Emission Tomography, Immunohistochemistry, Adenoid cystic carcinoma, Salivary duct carcinoma