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Theranostics 2020; 10(7):3083-3098. doi:10.7150/thno.41647 This issue Cite

Review

An evolving paradigm of cancer stem cell hierarchies: therapeutic implications

Alexander J Cole1, Adetunji P Fayomi1, Vivian I Anyaeche2, Shoumei Bai1, Ronald J Buckanovich3✉

1. Department of Internal Medicine and Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.
2. University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
3. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA

✉ Corresponding author: Dr. Ronald Buckanovich. Email: buckanovichrjmagee.edu

Citation:
Cole AJ, Fayomi AP, Anyaeche VI, Bai S, Buckanovich RJ. An evolving paradigm of cancer stem cell hierarchies: therapeutic implications. Theranostics 2020; 10(7):3083-3098. doi:10.7150/thno.41647. https://www.thno.org/v10p3083.htm
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Abstract

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Over a decade of research has confirmed the critical role of cancer stem-like cells (CSCs) in tumor initiation, chemoresistance, and metastasis. Increasingly, CSC hierarchies have begun to be defined with some recurring themes. This includes evidence that these hierarchies are 'flexible,' with both cell state transitions and dedifferentiation events possible. These findings pose therapeutic hurdles and opportunities. Here, we review cancer stem cell hierarchies and their interactions with the tumor microenvironment. We also discuss the current therapeutic approaches designed to target CSC hierarchies and initial clinical trial results for CSC targeting agents. While cancer stem cell targeted therapies are still in their infancy, we are beginning to see encouraging results that suggest a positive outlook for CSC-targeting approaches.

Citation styles

APA
Cole, A.J., Fayomi, A.P., Anyaeche, V.I., Bai, S., Buckanovich, R.J. (2020). An evolving paradigm of cancer stem cell hierarchies: therapeutic implications. Theranostics, 10(7), 3083-3098. https://doi.org/10.7150/thno.41647.

ACS
Cole, A.J.; Fayomi, A.P.; Anyaeche, V.I.; Bai, S.; Buckanovich, R.J. An evolving paradigm of cancer stem cell hierarchies: therapeutic implications. Theranostics 2020, 10 (7), 3083-3098. DOI: 10.7150/thno.41647.

NLM
Cole AJ, Fayomi AP, Anyaeche VI, Bai S, Buckanovich RJ. An evolving paradigm of cancer stem cell hierarchies: therapeutic implications. Theranostics 2020; 10(7):3083-3098. doi:10.7150/thno.41647. https://www.thno.org/v10p3083.htm

CSE
Cole AJ, Fayomi AP, Anyaeche VI, Bai S, Buckanovich RJ. 2020. An evolving paradigm of cancer stem cell hierarchies: therapeutic implications. Theranostics. 10(7):3083-3098.

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