Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma

Boot, Arnoud; Jiang, Nanhai; Rozen, Steven G.

doi:10.7150/thno.46489

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Theranostics 2020; 10(12):5578-5580. doi:10.7150/thno.46489 This issue Cite

Editorial

Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma

Arnoud Boot^1,2, Nanhai Jiang^1,2, Steven G. Rozen^{1,2,3,4 ✉}

1. Duke-NUS Centre for Computational Biology,Duke-NUS Medical School, 8 College Road, 169857 Singapore
2. Signature Research Programme in Cancer & Stem Cell Biology, Duke-NUS Medical School, 8 College Road, 169857 Singapore
3. SingHealth Duke-NUS Institute of Precision Medicine, 5 Hospital Drive 169609 Singapore
4. SingHealth Duke-NUS Global Health Institute, 8 College Road, 169857 Singapore

Citation:

Boot A, Jiang N, Rozen SG. Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. Theranostics 2020; 10(12):5578-5580. doi:10.7150/thno.46489. https://www.thno.org/v10p5578.htm

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Abstract

A cluster of patients poisoned by herbal medicine in the 1990s revealed that aristolochic acid (AA) causes kidney failure and upper tract urothelial carcinoma (UTUC). Recent research demonstrated that this was not an isolated incident; on the contrary, AA exposure is widespread in East Asia. This editorial highlights research by Lu and colleagues that investigates clinical characteristics of AA and non-AA UTUCs from 90 patients in Beijing based on the AA mutational signature. The study also detected AA mutations in non-tumor tissue of AA exposed patients and showed that AA mutations can be detected in urine, which might form the basis for non-invasive tests for AA exposure.

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APA

Boot, A., Jiang, N., Rozen, S.G. (2020). Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. Theranostics, 10(12), 5578-5580. https://doi.org/10.7150/thno.46489.

ACS

Boot, A.; Jiang, N.; Rozen, S.G. Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. Theranostics 2020, 10 (12), 5578-5580. DOI: 10.7150/thno.46489.

NLM

CSE

Boot A, Jiang N, Rozen SG. 2020. Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma. Theranostics. 10(12):5578-5580.

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