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Volume 10 (12); 2020

Editorial

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Toward clinical understanding of aristolochic acid upper-tract urothelial carcinoma
Arnoud Boot, Nanhai Jiang, Steven G. Rozen
Theranostics 2020; 10(12): 5578-5580. doi:10.7150/thno.46489
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Papers

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Selective delivery of T22-PE24-H6 to CXCR4+ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model
Aïda Falgàs, Victor Pallarès, Naroa Serna, Laura Sánchez-García, Jorge Sierra, Alberto Gallardo, Lorena Alba-Castellón, Patricia Álamo, Ugutz Unzueta, Antonio Villaverde, Esther Vázquez, Ramon Mangues, Isolda Casanova
Theranostics 2020; 10(12): 5169-5180. doi:10.7150/thno.43231
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC
Minji Lim, Juhee Park, Alarice C. Lowe, Hyoung-oh Jeong, Semin Lee, Hee Chul Park, Kyusang Lee, Gwang Ha Kim, Mi-Hyun Kim, Yoon-Kyoung Cho
Theranostics 2020; 10(12): 5181-5194. doi:10.7150/thno.44693
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tumor microenvironment-responsive multifunctional peptide coated ultrasmall gold nanoparticles and their application in cancer radiotherapy
Yuan Ding, Zhongquan Sun, Zongrui Tong, Sitong Zhang, Jie Min, Qianhui Xu, Liuzhi Zhou, Zhengwei Mao, Haibing Xia, Weilin Wang
Theranostics 2020; 10(12): 5195-5208. doi:10.7150/thno.45017
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dysregulated Sp1/miR-130b-3p/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma
Yadi Liao, Chenwei Wang, Zhiwen Yang, Wenwu Liu, Yichuan Yuan, Kai Li, Yuanping Zhang, Yongjin Wang, Yunxing Shi, Yuxiong Qiu, Dinglan Zuo, Wei He, Jiliang Qiu, Xinyuan Guan, Yunfei Yuan, Binkui Li
Theranostics 2020; 10(12): 5209-5224. doi:10.7150/thno.43640
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Parthenolide ameliorates colon inflammation through regulating Treg/Th17 balance in a gut microbiota-dependent manner
Yao-Jiang Liu, Bo Tang, Feng-Chao Wang, Li Tang, Yuan-Yuan Lei, Ya Luo, Sheng-Jie Huang, Min Yang, Ling-Yi Wu, Wei Wang, Shuang Liu, Shi-Ming Yang, Xiao-Yan Zhao
Theranostics 2020; 10(12): 5225-5241. doi:10.7150/thno.43716
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Discrete functional and mechanistic roles of chromodomain Y-like 2 (CDYL2) transcript variants in breast cancer growth and metastasis
Li-Feng Yang, Fan Yang, Fang-Lin Zhang, Yi-Fan Xie, Zhi-Xiang Hu, Sheng-Lin Huang, Zhi-Min Shao, Da-Qiang Li
Theranostics 2020; 10(12): 5242-5258. doi:10.7150/thno.43744
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition
Prahlad V. Raninga, Andy Lee, Debottam Sinha, Lan-feng Dong, Keshava K. Datta, Xue Lu, Priyakshi Kalita-de Croft, Mriga Dutt, Michelle Hill, Normand Pouliot, Harsha Gowda, Murugan Kalimutho, Jiri Neuzil, Kum Kum Khanna
Theranostics 2020; 10(12): 5259-5275. doi:10.7150/thno.42705
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Endothelial to mesenchymal transition contributes to nicotine-induced atherosclerosis
Wei Qin, Longyin Zhang, Zhange Li, Dan Xiao, Yue Zhang, Haiying Zhang, Justine Nyakango Mokembo, Seth Mikaye Monayo, Nabanit Kumar Jha, Philipp Kopylov, Dmitri Shchekochikhin, Yong Zhang
Theranostics 2020; 10(12): 5276-5289. doi:10.7150/thno.42470
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis
Kangpeng Jin, Yang Liu, Yuze Shi, Haitian Zhang, YuanYuan Sun, Guangyan Zhangyuan, Fei Wang, Weiwei Yu, Jincheng Wang, Xuewen Tao, Xin Chen, Wenjie Zhang, Beicheng Sun
Theranostics 2020; 10(12): 5290-5304. doi:10.7150/thno.42658
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Bio-orthogonal click-targeting nanocomposites for chemo-photothermal synergistic therapy in breast cancer
Jianan Qiao, Fengchun Tian, Yudi Deng, Yunkai Shang, Shijie Chen, Enhao Chang, Jing Yao
Theranostics 2020; 10(12): 5305-5321. doi:10.7150/thno.42445
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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PEX5, a novel target of microRNA-31-5p, increases radioresistance in hepatocellular carcinoma by activating Wnt/β-catenin signaling and homologous recombination
Jie Wen, Kai Xiong, Abudureyimujiang Aili, Hao Wang, Yuequan Zhu, Zhengquan Yu, Xueyan Yao, Ping Jiang, Lixiang Xue, Junjie Wang
Theranostics 2020; 10(12): 5322-5340. doi:10.7150/thno.42371
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke
Máté Pénzes, Demeter Túrós, Domokos Máthé, Krisztián Szigeti, Nikolett Hegedűs, Anna Ágnes Rauscher, Péter Tóth, Ivan Ivic, Parasuraman Padmanabhan, Gabriella Pál, Árpád Dobolyi, Máté Gyimesi, András Málnási-Csizmadia
Theranostics 2020; 10(12): 5341-5356. doi:10.7150/thno.42077
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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C-Met targeted fluorescence molecular endoscopy in Barrett's esophagus patients and identification of outcome parameters for phase-I studies
Steven J. de Jongh, Floris J. Voskuil, Iris Schmidt, Arend Karrenbeld, Gursah Kats-Ugurlu, Gert Jan Meersma, Jessie Westerhof, Max J.H. Witjes, Gooitzen M. van Dam, Dominic J. Robinson, Wouter B. Nagengast
Theranostics 2020; 10(12): 5357-5367. doi:10.7150/thno.42224
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Heritable modifiers of the tumor microenvironment influence nanoparticle uptake, distribution and response to photothermal therapy
Gayatri Sharma, Jaidip M. Jagtap, Abdul K. Parchur, Venkateswara R. Gogineni, Sophia Ran, Carmen Bergom, Sarah B. White, Michael J. Flister, Amit Joshi
Theranostics 2020; 10(12): 5368-5383. doi:10.7150/thno.41171
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeted sequencing reveals the mutational landscape responsible for sorafenib therapy in advanced hepatocellular carcinoma
Jing Tang, Cheng-Jun Sui, Dong-Fang Wang, Xin-Yuan Lu, Gui-Juan Luo, Qing Zhao, Qiu-Yu Lian, Seogsong Jeong, Xi-Meng Lin, Yan-Jing Zhu, Bo Zheng, Rui Wu, Qing Wang, Xiao-Long Liu, Jing-Feng Liu, Qiang Xia, Gang Wu, Jin Gu, Hong-Yang Wang, Lei Chen
Theranostics 2020; 10(12): 5384-5397. doi:10.7150/thno.41616
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Integrative metagenomic and metabolomic analyses reveal severity-specific signatures of gut microbiota in chronic kidney disease
I-Wen Wu, Sheng-Siang Gao, Hsin-Cheng Chou, Huang-Yu Yang, Lun-Ching Chang, Yu-Lun Kuo, Michael Cong Vinh Dinh, Wen-Hung Chung, Chi-Wei Yang, Hsin-Chih Lai, Wen-Ping Hsieh, Shih-Chi Su
Theranostics 2020; 10(12): 5398-5411. doi:10.7150/thno.41725
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification of a novel microRNA-141-3p/Forkhead box C1/β-catenin axis associated with rheumatoid arthritis synovial fibroblast function in vivo and in vitro
Jun Wang, Yin Wang, Hui Zhang, Jun Chang, Ming Lu, Weilu Gao, Wendong Liu, Yetian Li, Li Yin, Xiaohe Wang, Yuejun Wang, Mengru Gao, Zongsheng Yin
Theranostics 2020; 10(12): 5412-5434. doi:10.7150/thno.45214
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Molecular characteristics of synchronous multiple gastric cancer
Anqiang Wang, Zhongwu Li, Meng Wang, Shuqin Jia, Jiahu Chen, Ke Ji, Xin Ji, Xianglong Zong, Xiaojiang Wu, Ji Zhang, Ziyu Li, Lianhai Zhang, Ying Hu, Zhaode Bu, Qi Zheng, Jiafu Ji
Theranostics 2020; 10(12): 5489-5500. doi:10.7150/thno.42814
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy
Zhengrong Lin, Long Meng, Junjie Zou, Wei Zhou, Xiaowei Huang, Shan Xue, Tianyuan Bian, Tifei Yuan, Lili Niu, Yanwu Guo, Hairong Zheng
Theranostics 2020; 10(12): 5514-5526. doi:10.7150/thno.40520
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cytochrome P450 enzyme-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between clopidogrel and photosensitizer
Qiu Wang, Mengchi Sun, Dan Li, Chang Li, Cong Luo, Zhaomeng Wang, Wenjuan Zhang, Zimeng Yang, Yao Feng, Shuang Wang, Zhonggui He, Haotian Zhang, Qiming Kan, Wei Sun, Jin Sun
Theranostics 2020; 10(12): 5550-5564. doi:10.7150/thno.42633
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Chitosan modified Fe3O4/KGN self-assembled nanoprobes for osteochondral MR diagnose and regeneration
Yuping Hong, Yaguang Han, Jun Wu, Xinxin Zhao, Jin Cheng, Guo Gao, Qirong Qian, Xiuying Wang, Weidong Cai, Hala Zreiqat, Dagan Feng, Jianrong Xu, Daxiang Cui
Theranostics 2020; 10(12): 5565-5577. doi:10.7150/thno.43569
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism
Lan Sun, Peirong Lin, Ying Chen, Haoying Yu, Shuyu Ren, Jingrong Wang, Liyun Zhao, Guanhua Du
Theranostics 2020; 10(12): 5581-5599. doi:10.7150/thno.44687
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection
Zhongliang Shen, Jingwen Wu, Zixiang Gao, Jingyu Wang, Haoxiang Zhu, Richen Mao, Xuanyi Wang, Jiming Zhang, Youhua Xie, Jing Liu
Theranostics 2020; 10(12): 5600-5612. doi:10.7150/thno.44715
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CT quantification of pneumonia lesions in early days predicts progression to severe illness in a cohort of COVID-19 patients
Fengjun Liu, Qi Zhang, Chao Huang, Chunzi Shi, Lin Wang, Nannan Shi, Cong Fang, Fei Shan, Xue Mei, Jing Shi, Fengxiang Song, Zhongcheng Yang, Zezhen Ding, Xiaoming Su, Hongzhou Lu, Tongyu Zhu, Zhiyong Zhang, Lei Shi, Yuxin Shi
Theranostics 2020; 10(12): 5613-5622. doi:10.7150/thno.45985
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation
Yueyang Li, Zhenyu Xiong, Wenjun Yan, Erhe Gao, Hexiang Cheng, Guiling Wu, Yi Liu, Ling Zhang, Congye Li, Shan Wang, Miaomiao Fan, Huishou Zhao, Fuyang Zhang, Ling Tao
Theranostics 2020; 10(12): 5623-5640. doi:10.7150/thno.44836
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients
Qian Yu, Yuancheng Wang, Shan Huang, Songqiao Liu, Zhen Zhou, Shijun Zhang, Zhen Zhao, Yizhou Yu, Yi Yang, Shenghong Ju
Theranostics 2020; 10(12): 5641-5648. doi:10.7150/thno.46465
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
Laura Fusco, Arianna Gazzi, Guotao Peng, Yuyoung Shin, Sandra Vranic, Davide Bedognetti, Flavia Vitale, Acelya Yilmazer, Xinliang Feng, Bengt Fadeel, Cinzia Casiraghi, Lucia Gemma Delogu
Theranostics 2020; 10(12): 5435-5488. doi:10.7150/thno.40068
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Liquid biopsy for infectious diseases: a focus on microbial cell-free DNA sequencing
Dongsheng Han, Rui Li, Jiping Shi, Ping Tan, Rui Zhang, Jinming Li
Theranostics 2020; 10(12): 5501-5513. doi:10.7150/thno.45554
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing
Apresio K. Fajrial, Qing Qing He, Nurul I. Wirusanti, Jill E. Slansky, Xiaoyun Ding
Theranostics 2020; 10(12): 5532-5549. doi:10.7150/thno.43465
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Errata

Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis: Erratum
Tala, Songbo Xie, Xiaodong Sun, Xiaoou Sun, Jie Ran, Linlin Zhang, Dengwen Li, Min Liu, Gang Bao, Jun Zhou
Theranostics 2020; 10(12): 5527. doi:10.7150/thno.45566
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Erratum: βKlotho is identified as a target for theranostics in non-small cell lung cancer: Erratum
Fan Li, Xiyao Li, Ziming Li, Wenxiang Ji, Shun Lu, Weiliang Xia
Theranostics 2020; 10(12): 5528-5529. doi:10.7150/thno.46029
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis: Erratum
Suoyuan Li, Tao Zhang, Weiguo Xu, Jianxun Ding, Fei Yin, Jing Xu, Wei Sun, Hongsheng Wang, Mengxiong Sun, Zhengdong Cai, Yingqi Hua
Theranostics 2020; 10(12): 5530-5531. doi:10.7150/thno.46662
[Abstract] [Full text] [PDF] [PubMed] [PMC]