1. Université de Nantes, Institut de Cancérologie de l'Ouest, Saint-Herblain, F-44805, France. 2. SATT Ouest Valorisation, Nantes, France. 3. UFIP, Université de Nantes, CNRS, UMR 6286, Nantes, France. 4. Université de Nantes, INSERM, U1238, Nantes, France. 5. Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, UK.
✉ Corresponding authors: Dr Javier Muñoz-Garcia, Institut de Cancérologie de l'Ouest, Inserm U1232, Blvd Jacques Monod, 44805 Saint-Herblain, France. E-mail: javier.munozfr; Prof. Dominique Heymann, Institut de Cancérologie de l'Ouest, Blvd Jacques Monod, 44805 Saint-Herblain, France. E-mail: dominique.heymannfr; Tel.: +33 (0) 240 679 841.More
Citation:
Muñoz-Garcia J, Cochonneau D, Télétchéa S, Moranton E, Lanoe D, Brion R, Lézot F, Heymann MF, Heymann D. The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics 2021; 11(4):1568-1593. doi:10.7150/thno.50683. https://www.thno.org/v11p1568.htm
Macrophages are specialized cells that control tissue homeostasis. They include non-resident and tissue-resident macrophage populations which are characterized by the expression of particular cell surface markers and the secretion of molecules with a wide range of biological functions. The differentiation and polarization of macrophages relies on specific growth factors and their receptors. Macrophage-colony stimulating factor (CSF-1) and interleukine-34 (IL-34), also known as “twin” cytokines, are part of this regluatory landscape. CSF-1 and IL-34 share a common receptor, the macrophage-colony stimulating factor receptor (CSF-1R), which is activated in a similar way by both factors and turns on identical signaling pathways. However, there is some discrete differential activation leading to specific activities. In this review, we disscuss recent progress in understanding of the role of the twin cytokines in macrophage differentiation, from their interaction with CSF-1R and the activation of signaling pathways, to their implication in macrophage polarization of non-resident and tissue-resident macrophages. A special focus on IL-34, its involvement in pathophsyiological contexts, and its potential as a theranostic target for macrophage therapy will be proposed.
Muñoz-Garcia, J., Cochonneau, D., Télétchéa, S., Moranton, E., Lanoe, D., Brion, R., Lézot, F., Heymann, M.F., Heymann, D. (2021). The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics, 11(4), 1568-1593. https://doi.org/10.7150/thno.50683.
ACS
Muñoz-Garcia, J.; Cochonneau, D.; Télétchéa, S.; Moranton, E.; Lanoe, D.; Brion, R.; Lézot, F.; Heymann, M.F.; Heymann, D. The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics 2021, 11 (4), 1568-1593. DOI: 10.7150/thno.50683.
NLM
Muñoz-Garcia J, Cochonneau D, Télétchéa S, Moranton E, Lanoe D, Brion R, Lézot F, Heymann MF, Heymann D. The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics 2021; 11(4):1568-1593. doi:10.7150/thno.50683. https://www.thno.org/v11p1568.htm
CSE
Muñoz-Garcia J, Cochonneau D, Télétchéa S, Moranton E, Lanoe D, Brion R, Lézot F, Heymann MF, Heymann D. 2021. The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics. 11(4):1568-1593.
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