Theranostics 2021; 11(4):1568-1593. doi:10.7150/thno.50683 This issue Cite

Review

The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis

Javier Muñoz-Garcia1,2✉, Denis Cochonneau1, Stéphane Télétchéa3, Emilie Moranton1, Didier Lanoe1, Régis Brion4, Frédéric Lézot4, Marie-Françoise Heymann1, Dominique Heymann1,5✉

1. Université de Nantes, Institut de Cancérologie de l'Ouest, Saint-Herblain, F-44805, France.
2. SATT Ouest Valorisation, Nantes, France.
3. UFIP, Université de Nantes, CNRS, UMR 6286, Nantes, France.
4. Université de Nantes, INSERM, U1238, Nantes, France.
5. Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, UK.

Citation:
Muñoz-Garcia J, Cochonneau D, Télétchéa S, Moranton E, Lanoe D, Brion R, Lézot F, Heymann MF, Heymann D. The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics 2021; 11(4):1568-1593. doi:10.7150/thno.50683. https://www.thno.org/v11p1568.htm
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Abstract

Graphic abstract

Macrophages are specialized cells that control tissue homeostasis. They include non-resident and tissue-resident macrophage populations which are characterized by the expression of particular cell surface markers and the secretion of molecules with a wide range of biological functions. The differentiation and polarization of macrophages relies on specific growth factors and their receptors. Macrophage-colony stimulating factor (CSF-1) and interleukine-34 (IL-34), also known as “twin” cytokines, are part of this regluatory landscape. CSF-1 and IL-34 share a common receptor, the macrophage-colony stimulating factor receptor (CSF-1R), which is activated in a similar way by both factors and turns on identical signaling pathways. However, there is some discrete differential activation leading to specific activities. In this review, we disscuss recent progress in understanding of the role of the twin cytokines in macrophage differentiation, from their interaction with CSF-1R and the activation of signaling pathways, to their implication in macrophage polarization of non-resident and tissue-resident macrophages. A special focus on IL-34, its involvement in pathophsyiological contexts, and its potential as a theranostic target for macrophage therapy will be proposed.

Keywords: IL-34, inflammation, macrophage differentiation, theranostics, tumor


Citation styles

APA
Muñoz-Garcia, J., Cochonneau, D., Télétchéa, S., Moranton, E., Lanoe, D., Brion, R., Lézot, F., Heymann, M.F., Heymann, D. (2021). The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics, 11(4), 1568-1593. https://doi.org/10.7150/thno.50683.

ACS
Muñoz-Garcia, J.; Cochonneau, D.; Télétchéa, S.; Moranton, E.; Lanoe, D.; Brion, R.; Lézot, F.; Heymann, M.F.; Heymann, D. The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics 2021, 11 (4), 1568-1593. DOI: 10.7150/thno.50683.

NLM
Muñoz-Garcia J, Cochonneau D, Télétchéa S, Moranton E, Lanoe D, Brion R, Lézot F, Heymann MF, Heymann D. The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics 2021; 11(4):1568-1593. doi:10.7150/thno.50683. https://www.thno.org/v11p1568.htm

CSE
Muñoz-Garcia J, Cochonneau D, Télétchéa S, Moranton E, Lanoe D, Brion R, Lézot F, Heymann MF, Heymann D. 2021. The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis. Theranostics. 11(4):1568-1593.

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