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Volume 11 (4); 2021

Research Papers

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Photosensitizer-based multimodal PSMA-targeting ligands for intraoperative detection of prostate cancer
Yvonne H.W. Derks, Mark Rijpkema, Helene I.V. Amatdjais-Groenen, Annemarie Kip, Gerben M. Franssen, J. P. Michiel Sedelaar, Diederik M. Somford, Michiel Simons, Peter Laverman, Martin Gotthardt, Dennis W. P. M. Löwik, Susanne Lütje, Sandra Heskamp
Theranostics 2021; 11(4): 1527-1541. doi:10.7150/thno.52166
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia
Huizhong Xiong, Maicol Mancini, Michael Gobert, Shiqian Shen, Glaucia C. Furtado, Sergio A. Lira, Christopher N. Parkhurst, Veronique Garambois, Muriel Brengues, Carlos E. Tadokoro, Thomas Trimarchi, Gonzalo Gómez-López, Amartya Singh, Hossein Khiabanian, Sonia Minuzzo, Stefano Indraccolo, Camille Lobry, Iannis Aifantis, Daniel Herranz, Juan J. Lafaille, Antonio Maraver
Theranostics 2021; 11(4): 1594-1608. doi:10.7150/thno.48067
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling
Hongda Li, Yanfang Wang, Jiwen Liu, Xiaoli Chen, Yunhao Duan, Xiaoyu Wang, Yajing Shen, Yashu Kuang, Tao Zhuang, Brain Tomlinson, Paul Chan, Zuoren Yu, Yu Cheng, Lin Zhang, Zhongmin Liu, Yuzhen Zhang, Zhenlin Zhao, Qi Zhang, Jie Liu
Theranostics 2021; 11(4): 1609-1625. doi:10.7150/thno.48153
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis
Barbara Chiavarina, Brunella Costanza, Roberto Ronca, Arnaud Blomme, Sara Rezzola, Paola Chiodelli, Ambre Giguelay, Guillame Belthier, Gilles Doumont, Gaetan Van Simaeys, Simon Lacroix, Takehiko Yokobori, Bilguun Erkhem-Ochir, Patrick Balaguer, Vincent Cavailles, Eric Fabbrizio, Emmanuel Di Valentin, Stephanie Gofflot, Olivier Detry, Guy Jerusalem, Serge Goldman, Philippe Delvenne, Akeila Bellahcène, Julie Pannequin, Vincent Castronovo, Andrei Turtoi
Theranostics 2021; 11(4): 1626-1640. doi:10.7150/thno.51507
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Immunomodulation by systemic administration of human-induced pluripotent stem cell-derived mesenchymal stromal cells to enhance the therapeutic efficacy of cell-based therapy for treatment of myocardial infarction
Si-Jia Sun, Wing-Hon Lai, Yu Jiang, Zhe Zhen, Rui Wei, Qizhou Lian, Song-Yan Liao, Hung-Fat Tse
Theranostics 2021; 11(4): 1641-1654. doi:10.7150/thno.46119
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Neutrophil recruitment and leukocyte response following focused ultrasound and microbubble mediated blood-brain barrier treatments
Charissa Poon, Carly Pellow, Kullervo Hynynen
Theranostics 2021; 11(4): 1655-1671. doi:10.7150/thno.52710
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation
Licen Li, Jiaolin Bao, Haitao Wang, Josh Haipeng Lei, Cheng Peng, Jianming Zeng, Wenhui Hao, Xu Zhang, Xiaoling Xu, Chundong Yu, Chu-Xia Deng, Qiang Chen
Theranostics 2021; 11(4): 1672-1689. doi:10.7150/thno.47390
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I
Lujing Jiang, Xiaojian Yin, Ya-Hui Chen, Yan Chen, Wei Jiang, Hao Zheng, Feng-Qing Huang, Baolin Liu, Wei Zhou, Lian-Wen Qi, Jia Li
Theranostics 2021; 11(4): 1703-1720. doi:10.7150/thno.43895
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dual-mode endogenous and exogenous sensitization of tumor radiotherapy through antifouling dendrimer-entrapped gold nanoparticles
Chao Yang, Yue Gao, Yu Fan, Liu Cao, Jin Li, Yulong Ge, Wenzhi Tu, Yong Liu, Xueyan Cao, Xiangyang Shi
Theranostics 2021; 11(4): 1721-1731. doi:10.7150/thno.54930
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes
Lei Wang, Jia Yi, Ling-yun Lu, Yue-ying Zhang, Lan Wang, Guo-sheng Hu, Yi-chen Liu, Jian-cheng Ding, Hai-feng Shen, Fang-qing Zhao, Hai-hua Huang, Wen Liu
Theranostics 2021; 11(4): 1732-1752. doi:10.7150/thno.45302
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p
Jianxing Yin, Xin Ge, Zhumei Shi, Chen Yu, Chenfei Lu, Yutian Wei, Ailiang Zeng, Xiefeng Wang, Wei Yan, Junxia Zhang, Yongping You
Theranostics 2021; 11(4): 1763-1779. doi:10.7150/thno.47057
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Functional roles of antisense enhancer RNA for promoting prostate cancer progression
Chun-Wu Pan, Simeng Wen, Lei Chen, Yulei Wei, Yuanjie Niu, Yu Zhao
Theranostics 2021; 11(4): 1780-1794. doi:10.7150/thno.51931
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells
Yiping Wen, Yaya Hou, Xiaoqing Yi, Si Sun, Jing Guo, Xiaoqi He, Tao Li, Jing Cai, Zehua Wang
Theranostics 2021; 11(4): 1795-1813. doi:10.7150/thno.48101
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Retina as a window to cerebral dysfunction following studies with circRNA signature during neurodegeneration
Qin Jiang, Dong-Yuan Su, Zhen-Zhen Wang, Chang Liu, Ya-Nan Sun, Hong Cheng, Xiu-Miao Li, Biao Yan
Theranostics 2021; 11(4): 1814-1827. doi:10.7150/thno.51550
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Anti-allergic drug azelastine suppresses colon tumorigenesis by directly targeting ARF1 to inhibit IQGAP1-ERK-Drp1-mediated mitochondrial fission
Hui-Fang Hu, Wen Wen Xu, Yang-Jia Li, Yan He, Wei-Xia Zhang, Long Liao, Qi-Hua Zhang, Lei Han, Xing-Feng Yin, Xiao-Xu Zhao, Yun-Long Pan, Bin Li, Qing-Yu He
Theranostics 2021; 11(4): 1828-1844. doi:10.7150/thno.48698
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance
Meng Zhao, Yizhuo Wang, Ling Li, Shuyun Liu, Chengshi Wang, Yujia Yuan, Guang Yang, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Theranostics 2021; 11(4): 1845-1863. doi:10.7150/thno.50905
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Imaging atherosclerotic plaques by targeting Galectin-3 and activated macrophages using (89Zr)-DFO- Galectin3-F(ab')2 mAb
Zohreh Varasteh, Francesco De Rose, Sarajo Mohanta, Yuanfang Li, Xi Zhang, Benedikt Miritsch, Giorgia Scafetta, Changjun Yin, Hendrik B. Sager, Sarah Glasl, Dimitris Gorpas, Andreas J.R. Habenicht, Vasilis Ntziachristos, Wolfgang A. Weber, Armando Bartolazzi, Markus Schwaiger, Calogero D'Alessandria
Theranostics 2021; 11(4): 1864-1876. doi:10.7150/thno.50247
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress
Yute Yang, Panyang Shen, Teng Yao, Jun Ma, Zizheng Chen, Jinjin Zhu, Zhe Gong, Shuying Shen, Xiangqian Fang
Theranostics 2021; 11(4): 1877-1900. doi:10.7150/thno.53307
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A general Fc engineering platform for the next generation of antibody therapeutics
Da Chen, Yingjie Zhao, Mingyu Li, Hang Shang, Na Li, Fan Li, Wei Wang, Yuan Wang, Ruina Jin, Shiyu Liu, Xun Li, Shan Gao, Yujie Tian, Ruonan Li, Huanhuan Li, Yongyan Zhang, Mingjuan Du, Youjia Cao, Yan Zhang, Xin Li, Yi Huang, Liaoyuan A. Hu, Fubin Li, Hongkai Zhang
Theranostics 2021; 11(4): 1901-1917. doi:10.7150/thno.51299
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Development of the phenylpyrazolo[3,4-d]pyrimidine-based, insulin-like growth factor receptor/Src/AXL-targeting small molecule kinase inhibitor
Ho Jin Lee, Phuong Chi Pham, Honglan Pei, Bumhee Lim, Seung Yeob Hyun, Byungyeob Baek, Byungjin Kim, Yunha Kim, Min-Hwan Kim, Nae-Won Kang, Hye-Young Min, Dae-Duk Kim, Jeeyeon Lee, Ho-Young Lee
Theranostics 2021; 11(4): 1918-1936. doi:10.7150/thno.48865
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors
Qingbo Xu, Guiting Zhan, Zelong Zhang, Tuying Yong, Xiangliang Yang, Lu Gan
Theranostics 2021; 11(4): 1937-1952. doi:10.7150/thno.45511
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Increased photodynamic therapy sensitization in tumors using a nitric oxide-based nanoplatform with ATP-production blocking capability
Qinyanqiu Xiang, Bin Qiao, Yuanli Luo, Jin Cao, Kui Fan, Xinghua Hu, Lan Hao, Yang Cao, Qunxia Zhang, Zhigang Wang
Theranostics 2021; 11(4): 1953-1969. doi:10.7150/thno.52997
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Reducing PD-L1 expression with a self-assembled nanodrug: an alternative to PD-L1 antibody for enhanced chemo-immunotherapy
Shuxian Cai, Ziyi Chen, Yingjie Wang, Min Wang, Junye Wu, Yuhong Tong, Lanlan Chen, Chunhua Lu, Huanghao Yang
Theranostics 2021; 11(4): 1970-1981. doi:10.7150/thno.45777
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Fully end-to-end deep-learning-based diagnosis of pancreatic tumors
Ke Si, Ying Xue, Xiazhen Yu, Xinpei Zhu, Qinghai Li, Wei Gong, Tingbo Liang, Shumin Duan
Theranostics 2021; 11(4): 1982-1990. doi:10.7150/thno.52508
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma
Chuanhong Zhong, Bei Tao, Fangli Tang, Xiaobo Yang, Tangming Peng, Jian You, Kaiguo Xia, Xiangguo Xia, Ligang Chen, Lilei Peng
Theranostics 2021; 11(4): 1991-2005. doi:10.7150/thno.50613
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Integrated photodynamic Raman theranostic system for cancer diagnosis, treatment, and post-treatment molecular monitoring
Conor C. Horgan, Mads S. Bergholt, Anika Nagelkerke, May Zaw Thin, Isaac J. Pence, Ulrike Kauscher, Tammy L. Kalber, Daniel J. Stuckey, Molly M. Stevens
Theranostics 2021; 11(4): 2006-2019. doi:10.7150/thno.53031
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Nanomedicine of tyrosine kinase inhibitors
Veronika Smidova, Petr Michalek, Zita Goliasova, Tomas Eckschlager, Petr Hodek, Vojtech Adam, Zbynek Heger
Theranostics 2021; 11(4): 1546-1567. doi:10.7150/thno.48662
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis
Javier Muñoz-Garcia, Denis Cochonneau, Stéphane Télétchéa, Emilie Moranton, Didier Lanoe, Régis Brion, Frédéric Lézot, Marie-Françoise Heymann, Dominique Heymann
Theranostics 2021; 11(4): 1568-1593. doi:10.7150/thno.50683
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The 2020 race towards SARS-CoV-2 specific vaccines
Tomasz M. Karpiński, Marcin Ożarowski, Agnieszka Seremak-Mrozikiewicz, Hubert Wolski, Donald Wlodkowic
Theranostics 2021; 11(4): 1690-1702. doi:10.7150/thno.53691
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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YAP in pancreatic cancer: oncogenic role and therapeutic strategy
Wenhao Mao, Jia Mai, Hui Peng, Junhu Wan, Ting Sun
Theranostics 2021; 11(4): 1753-1762. doi:10.7150/thno.53438
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Errata

Ascorbic acid induced HepG2 cells' apoptosis via intracellular reductive stress: Erratum
Xiaonan Gao, Keyan Wei, Bo Hu, Kehua Xu, Bo Tang
Theranostics 2021; 11(4): 1542. doi:10.7150/thno.56023
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Blood TfR+ exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy: Erratum
Lijun Yang, Donglin Han, Qi Zhan, Xueping Li, Peipei Shan, Yunjie Hu, Han Ding, Yu Wang, Lei Zhang, Yuan Zhang, Sheng Xue, Jin Zhao, Xin Hou, Yin Wang, Peifeng Li, Xubo Yuan, Hongzhao Qi
Theranostics 2021; 11(4): 1543-1545. doi:10.7150/thno.55978
[Abstract] [Full text] [PDF] [PubMed] [PMC]