Theranostics 2021; 11(20):9859-9872. doi:10.7150/thno.65771 This issue Cite

Research Paper

Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm

Qian Jia1#, Zheng Li1#, Mingli Bai1, Haohao Yan1, Ruili Zhang1,2✉, Yu Ji1, Yanbin Feng1, Zuo Yang1, Zhongliang Wang1,2✉, Jianxiong Li3✉

1. Engineering Research Center of Molecular and Neuro-imaging of ministry of education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126 China.
2. Academy of Advanced Interdisciplinary Research, Xidian University, Xi'an, Shaanxi, 710071, China.
3. Department of Radiotherapy, Chinese PLA General Hospital, Beijing, 100071, China.
#These authors contributed equally to this work.

Citation:
Jia Q, Li Z, Bai M, Yan H, Zhang R, Ji Y, Feng Y, Yang Z, Wang Z, Li J. Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm. Theranostics 2021; 11(20):9859-9872. doi:10.7150/thno.65771. https://www.thno.org/v11p9859.htm
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Abstract

Graphic abstract

Peripheral artery disease (PAD) is a common, yet serious, circulatory condition that can increase the risk of amputation, heart attack or stroke. Accurate identification of PAD and dynamic monitoring of the treatment efficacy of PAD in real time are crucial for optimizing therapeutic outcomes. However, current imaging techniques do not enable these requirements.

Methods: A lanthanide-based nanoprobe with emission in the second near-infrared window b (NIR-IIb, 1500-1700 nm), Er-DCNPs, was utilized for continuous imaging of dynamic vascular structures and hemodynamic alterations in real time using PAD-related mouse models. The NIR-IIb imaging capability, stability, and biocompatibility of Er-DCNPs were evaluated in vitro and in vivo.

Results: Owing to their high temporal-spatial resolution in the NIR-IIb imaging window, Er-DCNPs not only exhibited superior capability in visualizing anatomical and pathophysiological features of the vasculature of mice but also provided dynamic information on blood perfusion for quantitative assessment of blood recovery, thereby achieving the synergistic integration of diagnostic and therapeutic imaging functions, which is very meaningful for the successful management of PAD.

Conclusion: Our findings indicate that Er-DCNPs can serve as a promising system to facilitate the diagnosis and treatment of PAD as well as other vasculature-related diseases.

Keywords: Lanthanide based nanoparticles, NIR-IIb imaging, vascular imaging, peripheral artery disease, ischemic reperfusion


Citation styles

APA
Jia, Q., Li, Z., Bai, M., Yan, H., Zhang, R., Ji, Y., Feng, Y., Yang, Z., Wang, Z., Li, J. (2021). Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm. Theranostics, 11(20), 9859-9872. https://doi.org/10.7150/thno.65771.

ACS
Jia, Q.; Li, Z.; Bai, M.; Yan, H.; Zhang, R.; Ji, Y.; Feng, Y.; Yang, Z.; Wang, Z.; Li, J. Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm. Theranostics 2021, 11 (20), 9859-9872. DOI: 10.7150/thno.65771.

NLM
Jia Q, Li Z, Bai M, Yan H, Zhang R, Ji Y, Feng Y, Yang Z, Wang Z, Li J. Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm. Theranostics 2021; 11(20):9859-9872. doi:10.7150/thno.65771. https://www.thno.org/v11p9859.htm

CSE
Jia Q, Li Z, Bai M, Yan H, Zhang R, Ji Y, Feng Y, Yang Z, Wang Z, Li J. 2021. Estimating dynamic vascular perfusion based on Er-based lanthanide nanoprobes with enhanced down-conversion emission beyond 1500 nm. Theranostics. 11(20):9859-9872.

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