Theranostics 2022; 12(6):2658-2673. doi:10.7150/thno.64244 This issue Cite

Research Paper

Wound microenvironment-responsive glucose consumption and hydrogen peroxide generation synergistic with azithromycin for diabetic wounds healing

Minqi Shi1,2, Zhen Du1,3✉, Yuchen Qi2, Wanlin Li2, Huiqun Hu5, Xiuhui Lin5, Shoujie Wang1,✉, Zhe Tang1,✉, Min Zhou1,2,4,✉

1. Department of Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China.
2. Institute of Translational Medicine, Zhejiang University, Hangzhou 310009, China.
3. The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
4. State Key Laboratory of Modern Optical Instrumentations, Zhejiang University, Hangzhou 310058, China.
5. Department of Infectious Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.

Citation:
Shi M, Du Z, Qi Y, Li W, Hu H, Lin X, Wang S, Tang Z, Zhou M. Wound microenvironment-responsive glucose consumption and hydrogen peroxide generation synergistic with azithromycin for diabetic wounds healing. Theranostics 2022; 12(6):2658-2673. doi:10.7150/thno.64244. https://www.thno.org/v12p2658.htm
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Abstract

Graphic abstract

Rationale: Chronic wounds are one of the common complications of diabetes. Due to the physiological conditions of diabetic patients, these wounds are more susceptible to bacterial infections and the formation of bacterial biofilms, leading to the inefficiency of conventional antibiotic treatment.

Methods: Here, hollow mesoporous silica nanoparticles (HMSN) were used as the nanocarriers for co-delivery of azithromycin (AZM) and glucose oxidase (GOX), achieving a remarkable synergistic effect in chronic diabetic wounds. GOX possesses the catalytic ability to consume glucose and produce H2O2 in the diabetic wound area. The down-regulation of local glucose could effectively improve the chronic diabetic wound microenvironment. Meanwhile, the generated H2O2 effectively inhibits bacterial growth and eradicates bacterial biofilms with the synergism of antibiotics AZM.

Results: In the bacteria-infected diabetic cutaneous wound models, the reduction of glucose, generation of H2O2, and release of AZM could effectively reduce the bacterial infection and promote the wounds healing. Moreover, there is no obvious toxicity behavior after the treatment.

Conclusions: Therefore, the designed nanosystem could effectively accelerate the diabetic wound healing process by the amelioration of the hyperglycemia microenvironment and the eradication of bacterial biofilms around the wounds, making them promising candidates for clinical transformation.

Keywords: silica nanoparticle, glucose oxidase, azithromycin, bacterial biofilm, diabetic wound healing


Citation styles

APA
Shi, M., Du, Z., Qi, Y., Li, W., Hu, H., Lin, X., Wang, S., Tang, Z., Zhou, M. (2022). Wound microenvironment-responsive glucose consumption and hydrogen peroxide generation synergistic with azithromycin for diabetic wounds healing. Theranostics, 12(6), 2658-2673. https://doi.org/10.7150/thno.64244.

ACS
Shi, M.; Du, Z.; Qi, Y.; Li, W.; Hu, H.; Lin, X.; Wang, S.; Tang, Z.; Zhou, M. Wound microenvironment-responsive glucose consumption and hydrogen peroxide generation synergistic with azithromycin for diabetic wounds healing. Theranostics 2022, 12 (6), 2658-2673. DOI: 10.7150/thno.64244.

NLM
Shi M, Du Z, Qi Y, Li W, Hu H, Lin X, Wang S, Tang Z, Zhou M. Wound microenvironment-responsive glucose consumption and hydrogen peroxide generation synergistic with azithromycin for diabetic wounds healing. Theranostics 2022; 12(6):2658-2673. doi:10.7150/thno.64244. https://www.thno.org/v12p2658.htm

CSE
Shi M, Du Z, Qi Y, Li W, Hu H, Lin X, Wang S, Tang Z, Zhou M. 2022. Wound microenvironment-responsive glucose consumption and hydrogen peroxide generation synergistic with azithromycin for diabetic wounds healing. Theranostics. 12(6):2658-2673.

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