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Review GRP78 in human diseases: From molecular chaperone to therapeutic target Yang Li, Dan Mu, Jiajie Feng, Zhijia Li, Lan Zhang, Lei Wang Theranostics 2026; 16(13): 7196-7243. doi:10.7150/thno.136060 Full text PDF


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Research Paper c-Met-targeted NIR-II imaging for precision management of oral squamous cell carcinoma and premalignant lesions Zhipeng Xia, Aiyan Ji, Qifan Ma, Yonghao Li, Hongyue Lou, Kun Qian, Jie Tian, Ying Yuan, Zhen Cheng, Xiaofeng Tao Theranostics 2026; 16(13): 7178-7195. doi:10.7150/thno.132350 Full text PDF


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Research Paper Intermittent hypoxia ameliorates behavioral deficits and exerts neurorestoration in a mouse photothrombotic stroke model Tao Wu, Shu Feng, Mengjie Chen, Xin Wang, Emily Parker, Li Gong, Luodan Yang, Rui Duan Theranostics 2026; 16(13): 7160-7177. doi:10.7150/thno.126126 Full text PDF


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Research Paper A clinically translatable, irreversibly attenuated Salmonella strain as a next-generation adjuvant for checkpoint immunotherapy Dinh-Huy Nguyen, Sung-Hwan You, Khuynh Van Nguyen, Phuong Thi-Minh Nguyen, Hien Thi-Thu Ngo, Khang Vuong Tran, Thanh Quang Tran, Miryoung Song, Yeongjin Hong, Jung-Joon Min Theranostics 2026; 16(13): 7139-7159. doi:10.7150/thno.129698 Full text PDF


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Research Paper DKK3–CKAP4 signaling drives fibroimmune remodeling and hair follicle miniaturization in androgenetic alopecia Seungchan An, Hyunju Kim, Mei Zheng, In Guk Park, Leegu Song, Jino Kim, Minsoo Noh, Jong-Hyuk Sung Theranostics 2026; 16(13): 7124-7138. doi:10.7150/thno.135412 Full text PDF


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Research Paper Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers Michael S. Valic, Esmat Najjar, Mark Zheng, Jason L. Townson, Harley H. L. Chan, Sharon Tzelnick, Alessandra Ruaro, Abdullah El-Sayes, Michael Halim, Pamela Schimmer, Chris J. Zhang, Tina Ye, Wenlei Jiang, Juan Chen, Jonathan C. Irish, Gang Zheng Theranostics 2026; 16(13): 7108-7123. doi:10.7150/thno.129853 Full text PDF

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Issue 10; 2026

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Founding Editor-in-Chief:
Prof. Xiaoyuan (Shawn) Chen, PhD
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Theranostics publishes innovative research articles reflecting the fields of in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensors, system biology and translational medicine, personalized medicine and a broad spectrum of biomedical research that can be applied to future theranostic applications.



Porphyrin-lipid nanotheranostics for multimodal imaging of nodal disease in preclinical oral cancers

Rationale: Cervical lymph node metastases in oral cancer patients are a frequent occurrence and important prognostic factor. Anatomical and molecular imaging modalities can identify neck metastases with varying sensitivity and specificity but perform poorly in clinically negative neck nodes with microscopic disease. Herein we investigate the use of porphyrin-lipid nanotheranostics (PS) for multimodal detection of neck disease in preclinical models ...

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