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Volume 14 (11); 2024

Research Papers

Graphic abstract

68Ga-labeled fibroblast activation protein inhibitor (FAPI) PET/CT for locally advanced or recurrent pancreatic cancer staging and restaging after chemoradiotherapy
Giulia Metzger, Christian Bayerl, Julian MM Rogasch, Christian Furth, Christoph Wetz, Marcus Beck, Felix Mehrhof, Holger Amthauer, Pirus Ghadjar, Christopher Neumann, Uwe Pelzer, Daniel Zips, Frank Hofheinz, Jane Grabowski, Imke Schatka, Sebastian Zschaeck
Theranostics 2024; 14(11): 4184-4197. doi:10.7150/thno.95329
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Aryl hydrocarbon receptor confers protection against macrophage pyroptosis and intestinal inflammation through regulating polyamine biosynthesis
Yajing Gao, Kwei-Yan Liu, Wenfeng Xiao, Xueru Xie, Qiuyan Liang, Zikun Tu, Lan Yang, Hongmiao Yu, Haiyan Guo, Saihua Huang, Xiao Han, Jinrong Fu, Yufeng Zhou
Theranostics 2024; 14(11): 4218-4239. doi:10.7150/thno.95749
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Pioneering noninvasive colorectal cancer detection with an AI-enhanced breath volatilomics platform
Yongqian Liu, Yongyan Ji, Jian Chen, Yixuan Zhang, Xiaowen Li, Xiang Li
Theranostics 2024; 14(11): 4240-4255. doi:10.7150/thno.94950
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Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis
Liangqi Chen, Meiju Zhang, Xueyan Yang, Yanan Wang, Tuo Huang, Xin Li, Yunting Ban, Qifeng Li, Qingyuan Yang, Yongxiang Zhang, Yang Zheng, Di Wang, Xiaoqi Wang, Xiujie Shi, Maomao Zhang, Yong Sun, Jian Wu
Theranostics 2024; 14(11): 4256-4277. doi:10.7150/thno.94738
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Graphic abstract

Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis
Ning Li, Lei Zhao, Xinyu Geng, Jingyang Liu, Xu Zhang, Ying Hu, Jihan Qi, Hongliang Chen, Jiawei Qiu, Xiaoyu Zhang, Shizhu Jin
Theranostics 2024; 14(11): 4278-4296. doi:10.7150/thno.96038
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Graphic abstract

Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation
Xiao-Yi Xiong, Xin-Ru Pan, Xia-Xia Luo, Yu-Fei Wang, Xin-Xiao Zhang, Su-Hao Yang, Zhan-Qiong Zhong, Chang Liu, Qiong Chen, Peng-Fei Wang, Xiao-Wei Chen, Shu-Guang Yu, Qing-Wu Yang
Theranostics 2024; 14(11): 4297-4317. doi:10.7150/thno.96375
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Palladium-103 (103Pd/103mRh), a promising Auger-electron emitter for targeted radionuclide therapy of disseminated tumor cells - absorbed doses in single cells and clusters, with comparison to 177Lu and 161Tb
Elif Hindié, Alexandre Larouze, Mario Alcocer-Ávila, Clément Morgat, Christophe Champion
Theranostics 2024; 14(11): 4318-4330. doi:10.7150/thno.95436
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Graphic abstract

Unlocking potential of oxytocin: improving intracranial lymphatic drainage for Alzheimer's disease treatment
Caihua Ye, Shengnan Wang, Lin Niu, Fan Yang, Guohe Wang, Siqi Wang, Jiamei Xie, Yihan Chen, Jinbo Qi, Hui Shen, Yan Dou, Junping Wang
Theranostics 2024; 14(11): 4331-4351. doi:10.7150/thno.98587
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Biomimetic nanoparticles with enhanced rapamycin delivery for autism spectrum disorder treatment via autophagy activation and oxidative stress modulation
Chenlin Miao, Yizhe Shen, Yue Lang, Hui Li, Yan Gong, Yamei Liu, Huafei Li, Byron C. Jones, Fuxue Chen, Shini Feng
Theranostics 2024; 14(11): 4375-4392. doi:10.7150/thno.95614
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Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis
Yajie Cai, Shuo Li, Yang Yang, Shuni Duan, Guifang Fan, Jinzhao Bai, Qi Zheng, Yiqing Gu, Xiaojiaoyang Li, Runping Liu
Theranostics 2024; 14(11): 4393-4410. doi:10.7150/thno.96184
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Cypher/ZASP drives cardiomyocyte maturation via actin-mediated MRTFA-SRF signalling
Jialan Lyu, Zhicheng Pan, Ruobing Li, Hailong Yu, Yuesheng Zhang, Dongfei Wang, Xiang Yin, Yan He, Liding Zhao, Siyuan Chen, Shan Zhang, Hongqiang Cheng, Xiaogang Guo
Theranostics 2024; 14(11): 4462-4480. doi:10.7150/thno.98734
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Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy
Kunjian Lei, Jingying Li, Zewei Tu, Chuandong Gong, Junzhe Liu, Min Luo, Wenqian Ai, Lei Wu, Yishuang Li, Zhihong Zhou, Zhihao Chen, Shigang Lv, Minhua Ye, Miaojing Wu, Xiaoyan Long, Xingen Zhu, Kai Huang
Theranostics 2024; 14(11): 4481-4498. doi:10.7150/thno.98574
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Rbm24/Notch1 signaling regulates adult neurogenesis in the subventricular zone and mediates Parkinson-associated olfactory dysfunction
Ke Wang, Xing-Yang Liu, Sui-Feng Liu, Xiao-Xia Wang, Yi-Hua Wei, Jun-Rong Zhu, Jing Liu, Xiu Qin Xu, Lei Wen
Theranostics 2024; 14(11): 4499-4518. doi:10.7150/thno.96045
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Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping
Sua Bae, Keyu Liu, Antonios N. Pouliopoulos, Robin Ji, Sergio Jiménez-Gambín, Omid Yousefian, Alina R. Kline-Schoder, Alec J. Batts, Fotios N. Tsitsos, Danae Kokossis, Akiva Mintz, Lawrence S. Honig, Elisa E. Konofagou
Theranostics 2024; 14(11): 4519-4535. doi:10.7150/thno.94206
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ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation
Na Cui, Chengyu Liu, Xiang Tang, Liangliang Song, Zixuan Xiao, Chen Wang, Yancai Wu, Yihao Zhou, Chentai Peng, Yuxia Liu, Ling Zheng, Xinran Liu, Kun Huang, Hong Chen
Theranostics 2024; 14(11): 4536-4553. doi:10.7150/thno.95796
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Reviews

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Multifunctional hydrogel-based engineered extracellular vesicles delivery for complicated wound healing
Zuhao Li, Jinlong Liu, Jian Song, Zhifeng Yin, Fengjin Zhou, Hao Shen, Guangchao Wang, Jiacan Su
Theranostics 2024; 14(11): 4198-4217. doi:10.7150/thno.97317
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Microfluidic chips in female reproduction: a systematic review of status, advances, and challenges
Tong Wu, Jinfeng Yan, Kebing Nie, Ying Chen, Yangyang Wu, Shixuan Wang, Jinjin Zhang
Theranostics 2024; 14(11): 4352-4374. doi:10.7150/thno.97301
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Graphic abstract

Nucleic acid-based nanotherapeutics for treating sepsis and associated organ injuries
Huang-Ping Yu, Fu-Chao Liu, Yu-Kuo Chung, Ahmed Alalaiwe, Calvin T. Sung, Jia-You Fang
Theranostics 2024; 14(11): 4411-4437. doi:10.7150/thno.98487
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Graphic abstract

Remote actuation and on-demand activation of biomaterials pre-incorporated with physical cues for bone repair
Xueping Kong, Tianyi Zheng, Zhaoyi Wang, Tong Zhou, Jiezhong Shi, Ying Wang, Ben Zhang
Theranostics 2024; 14(11): 4438-4461. doi:10.7150/thno.97610
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Erratum

Porphyrin-grafted Lipid Microbubbles for the Enhanced Efficacy of Photodynamic Therapy in Prostate Cancer through Ultrasound-controlled In Situ Accumulation: Erratum
Yujia You, Xiaolong Liang, Tinghui Yin, Min Chen, Chen Qiu, Chuang Gao, Xiaoyou Wang, Yongjiang Mao, Enze Qu, Zhifei Dai, Rongqin Zheng
Theranostics 2024; 14(11): 4554. doi:10.7150/thno.100601
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