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Volume 10 (2); 2020

Research Papers

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A tumor suppressor enhancing module orchestrated by GATA4 denotes a therapeutic opportunity for GATA4 deficient HCC patients
Feng Lu, Qian Zhou, Lu Liu, Guandi Zeng, Weimin Ci, Wanting Liu, Gong Zhang, Zhiyi Zhang, Peng Wang, Aiqun Zhang, Yunfei Gao, Lei Yu, Qingyu He, Liang Chen
Theranostics 2020; 10(2): 484-497. doi:10.7150/thno.38060
[Abstract] [Full text] [PDF]


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Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells
Lei Miao, Jingjing Qi, Qi Zhao, Qi-Nian Wu, Da-Liang Wei, Xiao-Li Wei, Jia Liu, Jun Chen, Zhao-Lei Zeng, Huai-Qiang Ju, Hui-yan Luo, Rui-Hua Xu
Theranostics 2020; 10(2): 498-515. doi:10.7150/thno.37745
[Abstract] [Full text] [PDF]


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ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells
Tianhui Pan, Jingwen Liu, Song Xu, Qiao Yu, Hongping Wang, Hongxiang Sun, Jia Wu, Yue Zhu, Jianwei Zhou, Yongliang Zhu
Theranostics 2020; 10(2): 516-536. doi:10.7150/thno.37472
[Abstract] [Full text] [PDF]


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WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer
Anna Kotrbová, Petra Ovesná, Tomáš Gybel', Tomasz Radaszkiewicz, Markéta Bednaříková, Jitka Hausnerová, Eva Jandáková, Luboš Minář, Igor Crha, Vít Weinberger, Luděk Záveský, Vítězslav Bryja, Vendula Pospíchalová
Theranostics 2020; 10(2): 537-552. doi:10.7150/thno.37423
[Abstract] [Full text] [PDF]


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NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression
Tao Wang, Mei Zhai, Sheng Xu, Murugavel Ponnusamy, Yan Huang, Cui-Yun Liu, Man Wang, Chan Shan, Pei-Pei Shan, Xiang-Qian Gao, Kai Wang, Xin-Zhe Chen, Jing Liu, Jing-Yi Xie, De-Yu Zhang, Lu-yu Zhou, Kun Wang
Theranostics 2020; 10(2): 553-566. doi:10.7150/thno.37181
[Abstract] [Full text] [PDF]


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Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect
Jeroen A.C.M. Goos, Andrew Cho, Lukas M. Carter, Thomas R. Dilling, Maria Davydova, Komal Mandleywala, Simon Puttick, Abhishek Gupta, William S. Price, John F. Quinn, Michael R. Whittaker, Jason S. Lewis, Thomas P. Davis
Theranostics 2020; 10(2): 567-584. doi:10.7150/thno.36777
[Abstract] [Full text] [PDF]


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In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects
Victoria Osinski, Dustin K. Bauknight, Siva Sai Krishna Dasa, Matthew J. Harms, Tobias Kroon, Melissa A. Marshall, James C. Garmey, Anh T. Nguyen, Julia Hartman, Aditi Upadhye, Prasad Srikakulapu, Andrea Zhou, Gavin O'Mahony, Alexander L. Klibanov, Kimberly A. Kelly, Jeremie Boucher, Coleen A. McNamara
Theranostics 2020; 10(2): 585-601. doi:10.7150/thno.36572
[Abstract] [Full text] [PDF]


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Mdig promotes oncogenic gene expression through antagonizing repressive histone methylation markers
Qian Zhang, Chitra Thakur, Yao Fu, Zhuoyue Bi, Priya Wadgaonkar, Liping Xu, Zhipeng Liu, Wanqing Liu, Jian Wang, Benjamin L. Kidder, Fei Chen
Theranostics 2020; 10(2): 602-614. doi:10.7150/thno.36220
[Abstract] [Full text] [PDF]


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Supramolecular nanomaterials based on hollow mesoporous drug carriers and macrocycle-capped CuS nanogates for synergistic chemo-photothermal therapy
Jie Yang, Dihua Dai, Xinyue Lou, Lianjun Ma, Bailiang Wang, Ying-Wei Yang
Theranostics 2020; 10(2): 615-629. doi:10.7150/thno.40066
[Abstract] [Full text] [PDF]


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Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues
Bhavesh D. Kevadiya, Brendan Ottemann, Insiya Z. Mukadam, Laura Castellanos, Kristen Sikora, James R. Hilaire, Jatin Machhi, Jonathan Herskovitz, Dhruvkumar Soni, Mahmudul Hasan, Wenting Zhang, Sarella Anandakumar, Jered Garrison, JoEllyn McMillan, Benson Edagwa, R. Lee Mosley, Richard W. Vachet, Howard E. Gendelman
Theranostics 2020; 10(2): 630-656. doi:10.7150/thno.39847
[Abstract] [Full text] [PDF]


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A supramolecular protein chaperone for vaccine delivery
Zhongyan Wang, Yuna Shang, Zhaoqi Tan, Xiaoyan Li, Guoliang Li, Chunhua Ren, Fuqiang Wang, Zhimou Yang, Jianfeng Liu
Theranostics 2020; 10(2): 657-670. doi:10.7150/thno.39132
[Abstract] [Full text] [PDF]


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Amplification-driven BCL6-suppressed cytostasis is mediated by transrepression of FOXO3 and post-translational modifications of FOXO3 in urinary bladder urothelial carcinoma
Wen-Ren Wu, Jen-Tai Lin, Cheng-Tang Pan, Ti-Chun Chan, Chen-Liang Liu, Wen-Jeng Wu, Jim Jinn-Chyuan Sheu, Bi-Wen Yeh, Steven K. Huang, Jheng-Yan Jhung, Meng-Shin Hsiao, Chien-Feng Li, Yow-Ling Shiue
Theranostics 2020; 10(2): 707-724. doi:10.7150/thno.39018
[Abstract] [Full text] [PDF]


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Mesenchymal stem cell-loaded thermosensitive hydroxypropyl chitin hydrogel combined with a three-dimensional-printed poly(ε-caprolactone) /nano-hydroxyapatite scaffold to repair bone defects via osteogenesis, angiogenesis and immunomodulation
Xiongfa Ji, Xi Yuan, Limin Ma, Bo Bi, Hao Zhu, Zehua Lei, Wenbin Liu, HongXu Pu, Jiawei Jiang, Xulin Jiang, Yu Zhang, Jun Xiao
Theranostics 2020; 10(2): 725-740. doi:10.7150/thno.39167
[Abstract] [Full text] [PDF]


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A sericin/ graphene oxide composite scaffold as a biomimetic extracellular matrix for structural and functional repair of calvarial bone
Chao Qi, Yan Deng, Luming Xu, Cheng Yang, Yuanyuan Zhu, Guobin Wang, Zheng Wang, Lin Wang
Theranostics 2020; 10(2): 741-756. doi:10.7150/thno.39502
[Abstract] [Full text] [PDF]


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Theranostic nanobubble encapsulating a plasmon-enhanced upconversion hybrid nanosystem for cancer therapy
Wen-Tse Huang, Ming-Hsien Chan, Xueyuan Chen, Michael Hsiao, Ru-Shi Liu
Theranostics 2020; 10(2): 782-796. doi:10.7150/thno.38684
[Abstract] [Full text] [PDF]


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Allosteric regulation of protein 14-3-3ζ scaffold by small-molecule editing modulates histone H3 post-translational modifications
Yan-Jun Wan, Li-Xi Liao, Yang Liu, Heng Yang, Xiao-Min Song, Li-Chao Wang, Xiao-Wen Zhang, Yi Qian, Dan Liu, Xiao-Meng Shi, Li-Wen Han, Qing Xia, Ke-Chun Liu, Zhi-Yong Du, Yong Jiang, Ming-Bo Zhao, Ke-Wu Zeng, Peng-Fei Tu
Theranostics 2020; 10(2): 797-815. doi:10.7150/thno.38483
[Abstract] [Full text] [PDF]


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In vivo photoacoustic imaging dynamically monitors the structural and functional changes of ischemic stroke at a very early stage
Jing Lv, Shi Li, Jinde Zhang, Fei Duan, Zhiyou Wu, Ronghe Chen, Maomao Chen, Shanshan Huang, Haosong Ma, Liming Nie
Theranostics 2020; 10(2): 816-828. doi:10.7150/thno.38554
[Abstract] [Full text] [PDF]


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Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression
Stephanie S. Kim, Shili Xu, Jing Cui, Soumya Poddar, Thuc M. Le, Hovhannes Hayrapetyan, Luyi Li, Nanping Wu, Alexandra M. Moore, Lei Zhou, Alice C. Yu, Amanda M. Dann, Irmina A. Elliott, Evan R. Abt, Woosuk Kim, David W. Dawson, Caius G. Radu, Timothy R. Donahue
Theranostics 2020; 10(2): 829-840. doi:10.7150/thno.40195
[Abstract] [Full text] [PDF]


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Biomineralized Bimetallic Oxide Nanotheranostics for Multimodal Imaging-Guided Combination Therapy
Jianrong Wu, Gareth R. Williams, Shiwei Niu, Yanbo Yang, Yu Li, Xuejing Zhang, Li-Min Zhu
Theranostics 2020; 10(2): 841-855. doi:10.7150/thno.40715
[Abstract] [Full text] [PDF]


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Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy
Louisa von Baumgarten, Jörg Kumbrink, Andreas Jung, Anna Reischer, Madeleine Flach, Sibylle Liebmann, Klaus H. Metzeler, Julian W. Holch, Maximilian Niyazi, Niklas Thon, Andreas Straube, Michael von Bergwelt-Baildon, Volker Heinemann, Thomas Kirchner, Christoph Benedikt Westphalen
Theranostics 2020; 10(2): 856-866. doi:10.7150/thno.36884
[Abstract] [Full text] [PDF]


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Red blood cell membrane-enveloped O2 self-supplementing biomimetic nanoparticles for tumor imaging-guided enhanced sonodynamic therapy
Cheng Li, Xiao-Quan Yang, Jie An, Kai Cheng, Xiao-Lin Hou, Xiao-Shuai Zhang, Yong-Guo Hu, Bo Liu, Yuan-Di Zhao
Theranostics 2020; 10(2): 867-879. doi:10.7150/thno.37930
[Abstract] [Full text] [PDF]


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High-resolution 3D visualization of nanomedicine distribution in tumors
Jennifer I. Moss, Hervé Barjat, Sally-Ann Emmas, Nicole Strittmatter, Juliana Maynard, Richard J. A. Goodwin, Gert Storm, Twan Lammers, Sanyogitta Puri, Marianne B. Ashford, Simon T. Barry
Theranostics 2020; 10(2): 880-897. doi:10.7150/thno.37178
[Abstract] [Full text] [PDF]


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Polymerase chain reaction - surface-enhanced Raman spectroscopy (PCR-SERS) method for gene methylation level detection in plasma
Xiaozhou Li, Tianyue Yang, Caesar Siqi Li, Youtao Song, Deli Wang, Lili Jin, Hong Lou, Wei Li
Theranostics 2020; 10(2): 898-909. doi:10.7150/thno.30204
[Abstract] [Full text] [PDF]


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Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation
Oriana Lo Re, Tommaso Mazza, Sebastiano Giallongo, Paola Sanna, Francesca Rappa, Tu Vinh Luong, Giovanni Li Volti, Adela Drovakova, Tania Roskams, Matthias Van Haele, Emmanuel Tsochatzis, Manlio Vinciguerra
Theranostics 2020; 10(2): 910-924. doi:10.7150/thno.35045
[Abstract] [Full text] [PDF]


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Cancer immunotherapy is accompanied by distinct metabolic patterns in primary and secondary lymphoid organs observed by non-invasive in vivo 18F-FDG-PET
Johannes Schwenck, Barbara Schörg, Francesco Fiz, Dominik Sonanini, Andrea Forschner, Thomas Eigentler, Benjamin Weide, Manuela Martella, Irene Gonzalez-Menendez, Cristina Campi, Gianmario Sambuceti, Ferdinand Seith, Leticia Quintanilla-Martinez, Claus Garbe, Christina Pfannenberg, Martin Röcken, Christian la Fougere, Bernd J Pichler, Manfred Kneilling
Theranostics 2020; 10(2): 925-937. doi:10.7150/thno.35989
[Abstract] [Full text] [PDF]

Reviews

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Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications
Lei Duan, Li Yang, Juan Jin, Fang Yang, Dong Liu, Ke Hu, Qinxin Wang, Yuanbin Yue, Ning Gu
Theranostics 2020; 10(2): 462-483. doi:10.7150/thno.37593
[Abstract] [Full text] [PDF]


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Carbon Dots as Potent Antimicrobial Agents
Xiuli Dong, Weixiong Liang, Mohammed J. Meziani, Ya-Ping Sun, Liju Yang
Theranostics 2020; 10(2): 671-686. doi:10.7150/thno.39863
[Abstract] [Full text] [PDF]


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Ferritins as natural and artificial nanozymes for theranostics
Bing Jiang, Long Fang, Kongming Wu, Xiyun Yan, Kelong Fan
Theranostics 2020; 10(2): 687-706. doi:10.7150/thno.39827
[Abstract] [Full text] [PDF]


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Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives
Linqiang Mei, Shuang Zhu, Wenyan Yin, Chunying Chen, Guangjun Nie, Zhanjun Gu, Yuliang Zhao
Theranostics 2020; 10(2): 757-781. doi:10.7150/thno.39701
[Abstract] [Full text] [PDF]


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Monoclonal antibody-based molecular imaging strategies and theranostic opportunities
Niels Dammes, Dan Peer
Theranostics 2020; 10(2): 938-955. doi:10.7150/thno.37443
[Abstract] [Full text] [PDF]