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Volume 11 (2); 2021

Research Papers

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Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions
Roman Mehling, Johannes Schwenck, Christina Lemberg, Christoph Trautwein, Laimdota Zizmare, Daniela Kramer, Anne Müller, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Katrin Schröder, Ralph P. Brandes, Martin Schaller, Wolfram Ruf, Martin Eichner, Kamran Ghoreschi, Martin Röcken, Bernd J. Pichler, Manfred Kneilling
Theranostics 2021; 11(2): 470-490. doi:10.7150/thno.51462
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inter and intra-tumor somatostatin receptor 2 heterogeneity influences peptide receptor radionuclide therapy response
Danny Feijtel, Gabriela N. Doeswijk, Nicole S. Verkaik, Joost C. Haeck, Daniela Chicco, Carmelina Angotti, Mark W. Konijnenberg, Marion de Jong, Julie Nonnekens
Theranostics 2021; 11(2): 491-505. doi:10.7150/thno.51215
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles
Wei Tong, Hui Hui, Wenting Shang, Yingqian Zhang, Feng Tian, Qiang Ma, Xin Yang, Jie Tian, Yundai Chen
Theranostics 2021; 11(2): 506-521. doi:10.7150/thno.49812
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats
Weilin Xu, Jun Yan, Umut Ocak, Cameron Lenahan, Anwen Shao, Jiping Tang, Jianmin Zhang, John H. Zhang
Theranostics 2021; 11(2): 522-539. doi:10.7150/thno.49426
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Boiling histotripsy and in-situ CD40 stimulation improve the checkpoint blockade therapy of poorly immunogenic tumors
Mohit Pratap Singh, Sri Nandhini Sethuraman, Craig Miller, Jerry Malayer, Ashish Ranjan
Theranostics 2021; 11(2): 540-554. doi:10.7150/thno.49517
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeting of glioma stem-like cells with a parthenolide derivative ACT001 through inhibition of AEBP1/PI3K/AKT signaling
Yanli Hou, Bowen Sun, Wenxue Liu, Bo Yu, Qiqi Shi, Fei Luo, Yongrui Bai, Haizhong Feng
Theranostics 2021; 11(2): 555-566. doi:10.7150/thno.49250
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CXCR4 PET imaging of mantle cell lymphoma using [68Ga]Pentixafor: comparison with [18F]FDG-PET
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Theranostics 2021; 11(2): 567-578. doi:10.7150/thno.48620
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cytosolic Ca2+ transients during pulsed focused ultrasound generate reactive oxygen species and cause DNA damage in tumor cells
Robert B. Rosenblatt, Joseph A. Frank, Scott R. Burks
Theranostics 2021; 11(2): 602-613. doi:10.7150/thno.48353
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein
Lin Wang, Junhu Zhou, Qixue Wang, Yunfei Wang, Chunsheng Kang
Theranostics 2021; 11(2): 649-664. doi:10.7150/thno.51479
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Expansion of murine and human olfactory epithelium/mucosa colonies and generation of mature olfactory sensory neurons under chemically defined conditions
Wenwen Ren, Li Wang, Xiujuan Zhang, Xiaoyu Feng, Liujing Zhuang, Nan Jiang, Rui Xu, Xuewen Li, Ping Wang, Xicai Sun, Hongmeng Yu, Yiqun Yu
Theranostics 2021; 11(2): 684-699. doi:10.7150/thno.46750
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1
Liang Wu, Ning Zhao, Zili Zhou, Jinhuang Chen, Shengbo Han, Xudan Zhang, Haijun Bao, Wenzheng Yuan, Xiaogang Shu
Theranostics 2021; 11(2): 700-714. doi:10.7150/thno.47800
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis
Zhao-Lan Hu, Cong Luo, Plinio Reinaldo Hurtado, Hui Li, Shuang Wang, Bo Hu, Jun-Mei Xu, Yang Liu, Shi-Qing Feng, Ernesto Hurtado-Perez, Kang Chen, Xin-Fu Zhou, Chang-Qi Li, Ru-Ping Dai
Theranostics 2021; 11(2): 715-730. doi:10.7150/thno.51390
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis
Chao Chen, Guixue Hou, Chunwei Zeng, Yan Ren, Xiang Chen, Cong Peng
Theranostics 2021; 11(2): 754-767. doi:10.7150/thno.51154
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Implantation of regenerative complexes in traumatic brain injury canine models enhances the reconstruction of neural networks and motor function recovery
Jipeng Jiang, Chen Dai, Xiaoyin Liu, Lujia Dai, Ruixin Li, Ke Ma, Huiyou Xu, Fei Zhao, Zhiwen Zhang, Tao He, Xuegang Niu, Xuyi Chen, Sai Zhang
Theranostics 2021; 11(2): 768-788. doi:10.7150/thno.50540
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain
Fadi Rofo, Canan Ugur Yilmaz, Nicole Metzendorf, Tobias Gustavsson, Chiara Beretta, Anna Erlandsson, Dag Sehlin, Stina Syvänen, Per Nilsson, Greta Hultqvist
Theranostics 2021; 11(2): 789-804. doi:10.7150/thno.50263
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation
Jie Hu, Qingzhu Gao, Yang Yang, Jie Xia, Wanjun Zhang, Yao Chen, Zhi Zhou, Lei Chang, Yuan Hu, Hui Zhou, Li Liang, Xiaosong Li, Quanxin Long, Kai Wang, Ailong Huang, Ni Tang
Theranostics 2021; 11(2): 805-823. doi:10.7150/thno.50230
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A novel STAT3 inhibitor W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance
Qiyao Zheng, Hui Dong, Jianshan Mo, Yi Zhang, Jie Huang, Shumin Ouyang, Shuo Shi, Kai Zhu, Xinming Qu, Wenhao Hu, Peiqing Liu, Yuanxiang Wang, Xiaolei Zhang
Theranostics 2021; 11(2): 824-840. doi:10.7150/thno.49600
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3
Lijie Zhou, Zhengshuai Song, Junyi Hu, Lilong Liu, Yaxin Hou, Xiaoping Zhang, Xiong Yang, Ke Chen
Theranostics 2021; 11(2): 841-860. doi:10.7150/thno.49384
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury
Yuanyuan Cheng, Liangkai Cheng, Xiang Gao, Sixuan Chen, Peng Wu, Caiyan Wang, Zhongqiu Liu
Theranostics 2021; 11(2): 861-877. doi:10.7150/thno.48436
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Discovery of extracellular vesicles derived miR-181a-5p in patient's serum as an indicator for bone-metastatic prostate cancer
Yanqing Wang, Yu-Xiang Fang, Baijun Dong, Xinxing Du, Jialin Wang, Xiao Wang, Wei-Qiang Gao, Wei Xue
Theranostics 2021; 11(2): 878-892. doi:10.7150/thno.49186
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis
Tao Cheng, Shuai Ding, Shanshan Liu, Yan Li, Lingyun Sun
Theranostics 2021; 11(2): 893-905. doi:10.7150/thno.48080
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Collagenase IV and clusterin-modified polycaprolactone-polyethylene glycol nanoparticles for penetrating dense tumor tissues
Hao-Yan Huang, Li-Qing Chen, Wei Sun, Huan-Huan Du, Shunli Dong, Atef Mohammed Qasem Ahmed, Dingyun Cao, Jing-Hao Cui, Yi Zhang, Qing-Ri Cao
Theranostics 2021; 11(2): 906-924. doi:10.7150/thno.47446
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LncRNA BCYRN1-induced autophagy enhances asparaginase resistance in extranodal NK/T-cell lymphoma
Liang Wang, Jing Yang, He-nan Wang, Rui-ying Fu, Xin-di Liu, Ying-shi Piao, Li-qiang Wei, Jing-wen Wang, Luo Zhang
Theranostics 2021; 11(2): 925-940. doi:10.7150/thno.46655
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Extra-domain B of fibronectin as an alternative target for drug delivery and a cancer diagnostic and prognostic biomarker for malignant glioma
Phei Er Saw, Xiaoding Xu, Bo Ram Kang, Jungsul Lee, Yeo Song Lee, Chungyeul Kim, Hyungsin Kim, Shin-Hyuk Kang, Yoo Jin Na, Hong Joo Moon, Joo Han Kim, Youn-Kwan Park, Wonki Yoon, Jong Hyun Kim, Taek-Hyun Kwon, Chulhee Choi, Sangyong Jon, Kyuha Chong
Theranostics 2021; 11(2): 941-957. doi:10.7150/thno.44948
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Bruceantin targets HSP90 to overcome resistance to hormone therapy in castration-resistant prostate cancer
Sue Jin Moon, Byong Chang Jeong, Hwa Jin Kim, Joung Eun Lim, Hye-Jeong Kim, Ghee Young Kwon, Joshua A. Jackman, Jeong Hoon Kim
Theranostics 2021; 11(2): 958-973. doi:10.7150/thno.51478
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Molecular machineries and physiological relevance of ER-mediated membrane contacts
Shiyin Lin, Tian Meng, Haofeng Huang, Haixia Zhuang, Zhengjie He, Huan Yang, Du Feng
Theranostics 2021; 11(2): 974-995. doi:10.7150/thno.51871
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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MRI-traceable theranostic nanoparticles for targeted cancer treatment
Tareq Anani, Shiva Rahmati, Nayer Sultana, Allan E. David
Theranostics 2021; 11(2): 579-601. doi:10.7150/thno.48811
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
Song Zhang, Jiangtao Shen, Dali Li, Yiyun Cheng
Theranostics 2021; 11(2): 614-648. doi:10.7150/thno.47007
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Glioma stem cells and their roles within the hypoxic tumor microenvironment
Nathaniel H. Boyd, Anh Nhat Tran, Joshua D. Bernstock, Tina Etminan, Amber B. Jones, G. Yancey Gillespie, Gregory K. Friedman, Anita B. Hjelmeland
Theranostics 2021; 11(2): 665-683. doi:10.7150/thno.41692
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges
Anup S. Pathania, Philip Prathipati, Bakrudeen AA. Abdul, Srinivas Chava, Santharam S. Katta, Subash C. Gupta, Pandu R. Gangula, Manoj K. Pandey, Donald L. Durden, Siddappa N. Byrareddy, Kishore B. Challagundla
Theranostics 2021; 11(2): 731-753. doi:10.7150/thno.51471
[Abstract] [Full text] [PDF] [PubMed] [PMC]