Special Issue

The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy

Guest editors:

Yang Shi (RWTH Aachen University), Roy van der Meel (Eindhoven University of Technology), Xiaoyuan (Shawn) Chen (NIBIB/NIH), and Twan Lammers (RWTH Aachen University)


Editorial
The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy
Yang Shi, Roy van der Meel, Xiaoyuan Chen, Twan Lammers
Theranostics 2020; 10(17): 7921-7924. doi:10.7150/thno.49577
[Abstract] [Full text] [PDF]


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Transcytosis - An effective targeting strategy that is complementary to “EPR effect” for pancreatic cancer nano drug delivery
Xiangsheng Liu, Jinhong Jiang, Huan Meng
2019; 9(26): 8018-8025. doi:10.7150/thno.38587
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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EPR-mediated tumor targeting using ultrasmall-hybrid nanoparticles: From animal to human with theranostic AGuIX nanoparticles
Guillaume Bort, François Lux, Sandrine Dufort, Yannick Crémillieux, Camille Verry, Olivier Tillement
2020; 10(3): 1319-1331. doi:10.7150/thno.37543
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Probing and Enhancing Ligand-Mediated Active Targeting of Tumors Using Sub-5 nm Ultrafine Iron Oxide Nanoparticles
Yaolin Xu, Hui Wu, Jing Huang, Weiping Qian, Deborah E. Martinson, Bing Ji, Yuancheng Li, Yongqiang A. Wang, Lily Yang, Hui Mao
2020; 10(6): 2479-2494. doi:10.7150/thno.39560
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment
Jooho Park, Yongwhan Choi, Hyeyoun Chang, Wooram Um, Ju Hee Ryu, Ick Chan Kwon
2019; 9(26): 8073-8090. doi:10.7150/thno.37198
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Improving accessibility of EPR-insensitive tumor phenotypes using EPR-adaptive strategies: Designing a new perspective in nanomedicine delivery
Alexander Dhaliwal, Gang Zheng
2019; 9(26): 8091-8108. doi:10.7150/thno.37204
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications
Lei Duan, Li Yang, Juan Jin, Fang Yang, Dong Liu, Ke Hu, Qinxin Wang, Yuanbin Yue, Ning Gu
2020; 10(2): 462-483. doi:10.7150/thno.37593
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
Maria Tsioumpekou, Sara I. Cunha, Haisha Ma, Aive Åhgren, Jessica Cedervall, Anna-Karin Olsson, Carl-Henrik Heldin, Johan Lennartsson
2020; 10(3): 1122-1135. doi:10.7150/thno.37851
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Monoclonal antibody-based molecular imaging strategies and theranostic opportunities
Niels Dammes, Dan Peer
2020; 10(2): 938-955. doi:10.7150/thno.37443
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging
Henriette S. de Bruijn, Vida Mashayekhi, Tom J.L. Schreurs, Pieter B.A.A. van Driel, Gustav J. Strijkers, Paul J. van Diest, Clemens W.G.M. Lowik, Ann L.B. Seynhaeve, Timo L.M. ten Hagen, Jeanine J. Prompers, Paul M.P. van Bergen en Henegouwen, Dominic J. Robinson, Sabrina Oliveira
2020; 10(5): 2436-2452. doi:10.7150/thno.37949
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy
Olga B. Garbuzenko, Andriy Kuzmov, Oleh Taratula, Sharon R. Pine, Tamara Minko
2019; 9(26): 8362-8376. doi:10.7150/thno.39816
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cyclic RGD-Functionalized and Disulfide-Crosslinked Iodine-Rich Polymersomes as a Robust and Smart Theranostic Agent for Targeted CT Imaging and Chemotherapy of Tumor
Yan Zou, Yaohua Wei, Yinping Sun, Jie Bao, Feirong Yao, Zekun Li, Fenghua Meng, Chunhong Hu, Gert Storm, Zhiyuan Zhong
2019; 9(26): 8061-8072. doi:10.7150/thno.37184
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Nanocarrier-based drug combination therapy for glioblastoma
Mengnan Zhao, Demian van Straten, Marike L.D. Broekman, Véronique Préat, Raymond M. Schiffelers
2020; 10(3): 1355-1372. doi:10.7150/thno.38147
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Advances in nanomedicine for cancer starvation therapy
Shuangjiang Yu, Zhaowei Chen, Xuan Zeng, Xuesi Chen, Zhen Gu
2019; 9(26): 8026-8047. doi:10.7150/thno.38261
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy
Jianzhi Zhu, Zhicong Li, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi, Han Wang, Jan C. M. van Hest
2019; 9(26): 8048-8060. doi:10.7150/thno.37054
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Extracellular vesicle-based drug delivery systems for cancer treatment
Sierra Walker, Sara Busatto, Anthony Pham, Ming Tian, Annie Suh, Kelsey Carson, Astrid Quintero, Maria Lafrence, Hanna Malik, Moises X. Santana, Joy Wolfram
2019; 9(26): 8001-8017. doi:10.7150/thno.37097
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics
Peng Mi
2020; 10(10): 4557-4588. doi:10.7150/thno.38069
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Engineering Nanoparticles to Reprogram the Tumor Immune Microenvironment for Improved Cancer Immunotherapy
Madiha Saeed, Jing Gao, Yang Shi, Twan Lammers, Haijun Yu
2019; 9(26): 7981-8000. doi:10.7150/thno.37568
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity
Myrofora Panagi, Chrysovalantis Voutouri, Fotios Mpekris, Panagiotis Papageorgis, Margaret R Martin, John D Martin, Philippos Demetriou, Chryso Pierides, Christiana Polydorou, Andreas Stylianou, Maria Louca, Laura Koumas, Paul Costeas, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
2020; 10(4): 1910-1922. doi:10.7150/thno.36936
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Improving nanotherapy delivery and action through image-guided systems pharmacology
Thomas S.C. Ng, Michelle A. Garlin, Ralph Weissleder, Miles A. Miller
2020; 10(3): 968-997. doi:10.7150/thno.37215
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Imaging-assisted anticancer nanotherapy
Anshuman Dasgupta, Ilaria Biancacci, Fabian Kiessling, Twan Lammers
2020; 10(3): 956-967. doi:10.7150/thno.38288
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment
Josanne Sophia de Maar, Alexandros Marios Sofias, Tiffany Porta Siegel, Rob J. Vreeken, Chrit Moonen, Clemens Bos, Roel Deckers
2020; 10(4): 1884-1909. doi:10.7150/thno.38625
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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High-resolution 3D visualization of nanomedicine distribution in tumors
Jennifer I. Moss, Hervé Barjat, Sally-Ann Emmas, Nicole Strittmatter, Juliana Maynard, Richard J. A. Goodwin, Gert Storm, Twan Lammers, Sanyogitta Puri, Marianne B. Ashford, Simon T. Barry
2020; 10(2): 880-897. doi:10.7150/thno.37178
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging
Bowen Qi, Ayrianne J. Crawford, Nicholas E. Wojtynek, Geoffrey A. Talmon, Michael A. Hollingsworth, Quan P. Ly, Aaron M. Mohs
2020; 10(8): 3413-3429. doi:10.7150/thno.40688
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Delivery of polymeric nanostars for molecular imaging and endoradiotherapy through the enhanced permeability and retention (EPR) effect
Jeroen A.C.M. Goos, Andrew Cho, Lukas M. Carter, Thomas R. Dilling, Maria Davydova, Komal Mandleywala, Simon Puttick, Abhishek Gupta, William S. Price, John F. Quinn, Michael R. Whittaker, Jason S. Lewis, Thomas P. Davis
2020; 10(2): 567-584. doi:10.7150/thno.36777
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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