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Volume 11 (10); 2021

Research Papers

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Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation
Zih-Chan Lin, Tsong-Long Hwang, Tse-Hung Huang, Kohei Tahara, Jiří Trousil, Jia-You Fang
Theranostics 2021; 11(10): 4567-4584. doi:10.7150/thno.56995
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Mutational spectrum and precision oncology for biliary tract carcinoma
Jianzhen Lin, Yinghao Cao, Xu Yang, Guangyu Li, Yang Shi, Dongxu Wang, Junyu Long, Yang Song, Jinzhu Mao, Fucun Xie, Yi Bai, Lei Zhang, Xiaobo Yang, Xueshuai Wan, Anqiang Wang, Mei Guan, Lin Zhao, Ke Hu, Jie Pan, Li Huo, Xin Lu, Yilei Mao, Xinting Sang, Henghui Zhang, Kai Wang, Xiaoyue Wang, Haitao Zhao
Theranostics 2021; 11(10): 4585-4598. doi:10.7150/thno.56539
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma
Yan-yang Gao, Zhuo-yan Ling, Yun-Rong Zhu, Ce Shi, Yin Wang, Xiang-yang Zhang, Zhi-qing Zhang, Qin Jiang, Min-Bin Chen, Shuofei Yang, Cong Cao
Theranostics 2021; 11(10): 4599-4615. doi:10.7150/thno.55655
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Decreased neuronal synaptosome associated protein 29 contributes to poststroke cognitive impairment by disrupting presynaptic maintenance
Weijie Yan, Jiahui Fan, Xia Zhang, Huimeng Song, Rongqi Wan, Wei Wang, Yanling Yin
Theranostics 2021; 11(10): 4616-4636. doi:10.7150/thno.54210
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway
Wei Xiong, Zhiyong Xiong, Anni Song, Chuntao Lei, Chen Ye, Chun Zhang
Theranostics 2021; 11(10): 4637-4654. doi:10.7150/thno.56082
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Aurka loss in CD19+ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production
Xin Chen, Chennan Wang, Na Sun, Shuai Pan, Rongqing Li, Xueqin Li, Jie Zhao, Huan Tong, Yangyang Tang, Jing Han, Jianlin Qiao, Hongbin Qiu, Hui Wang, Jing Yang, Takayuki Ikezoe
Theranostics 2021; 11(10): 4655-4671. doi:10.7150/thno.49007
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy
Szu-Jung Chen, Li-Hsien Chen, Yu-Min Yeh, Chou-Ching K Lin, Peng-Chan Lin, Han-Wei Huang, Meng-Ru Shen, Bo-Wen Lin, Jeng-Chang Lee, Cheng-Che Lee, Yueh-Feng Lee, Huai-Chueh Chiang, Jang-Yang Chang
Theranostics 2021; 11(10): 4672-4687. doi:10.7150/thno.54793
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Synthesis of RNA-based gene regulatory devices for redirecting cellular signaling events mediated by p53
Xinbo Huang, Mingxia Wang, Yuchen Liu, Yaoting Gui
Theranostics 2021; 11(10): 4688-4698. doi:10.7150/thno.55856
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Peripheral eosinophil counts predict efficacy of anti-CD19 CAR-T cell therapy against B-lineage non-Hodgkin lymphoma
Qingzhu Jia, Diyuan Qin, Feng He, Qichao Xie, Zhitao Ying, Yajing Zhang, Yuqin Song, Jia-Nan Cheng, Xuejiao Zuo, Luxiang Xu, Hongliang Fang, Chunyan Hu, Lina Peng, Tao Jin, Zixiao Shi, Peter B. Alexander, Yongsheng Wang, Yarong Liu, Weidong Han, Jun Zhu, Pin Wang, Qi-Jing Li, Bo Zhu
Theranostics 2021; 11(10): 4699-4709. doi:10.7150/thno.54546
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice via p53/PPARα signaling
Yin Cai, Hao Liu, Erfei Song, Lin Wang, Jindong Xu, Yi He, Dengwen Zhang, Liyan Zhang, Kenneth King-yip Cheng, Leigang Jin, Min Wu, Shiming Liu, Dake Qi, Liangqing Zhang, Gary D. Lopaschuk, Sheng Wang, Aimin Xu, Zhengyuan Xia
Theranostics 2021; 11(10): 4710-4727. doi:10.7150/thno.51739
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity
Jian Lu, Pei Pei Chen, Jia Xiu Zhang, Xue Qi Li, Gui Hua Wang, Ben Yin Yuan, Si Jia Huang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Zhong Ruan, Bi Cheng Liu, Kun Ling Ma
Theranostics 2021; 11(10): 4728-4742. doi:10.7150/thno.56598
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of TGFβ1 accelerates regeneration of fibrotic rat liver elicited by a novel two-staged hepatectomy
Bo Zhang, Fanzheng Meng, Yao Liu, Yubin Yuan, Jizhou Wang, Dehai Wu, Yifeng Cui, Shugeng Zhang, Hongrui Guo, Shuhang Liang, Wei Wang, Matthew Klos, Sherry Morgenstern, Yufeng Liu, Linmao Sun, Kun Ma, Xirui Liu, Yan Wang, Jihua Han, Guangchao Yang, Chenyang Zheng, Xianying Li, Shuo Zhou, Changyong Ji, Qingquan Bai, Jiabei Wang, Lianxin Liu
Theranostics 2021; 11(10): 4743-4758. doi:10.7150/thno.52102
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Vertebral-specific activation of the CX3CL1/ICAM-1 signaling network mediates non-small-cell lung cancer spinal metastasis by engaging tumor cell-vertebral bone marrow endothelial cell interactions
Ketao Wang, Libo Jiang, Annan Hu, Chi Sun, Lei Zhou, Yiwei Huang, Qing Chen, Jian Dong, Xiaogang Zhou, Feng Zhang
Theranostics 2021; 11(10): 4770-4789. doi:10.7150/thno.54235
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Thyroid hormone plus dual-specificity phosphatase-5 siRNA increases the number of cardiac muscle cells and improves left ventricular contractile function in chronic doxorubicin-injured hearts
Lin Tan, Nikolay Bogush, Emmen Naqvi, John W. Calvert, Robert M. Graham, W. Robert Taylor, Nawazish Naqvi, Ahsan Husain
Theranostics 2021; 11(10): 4790-4808. doi:10.7150/thno.57456
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer
Qianghua Zhou, Xu Chen, Haixia He, Shengmeng Peng, Yangjie Zhang, Jingtong Zhang, Liang Cheng, Sen Liu, Ming Huang, Ruihui Xie, Tianxin Lin, Jian Huang
Theranostics 2021; 11(10): 4809-4824. doi:10.7150/thno.55814
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux
Feiye Zhou, Linlin Zhang, Kecheng Zhu, Mengyao Bai, Yuqing Zhang, Qin Zhu, Shushu Wang, Chunxiang Sheng, Miaomiao Yuan, Yun Liu, Jieli Lu, Li Shao, Xiao Wang, Libin Zhou
Theranostics 2021; 11(10): 4825-4838. doi:10.7150/thno.55330
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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In vivo fermentation production of humanized noncoding RNAs carrying payload miRNAs for targeted anticancer therapy
Peng-Cheng Li, Mei-Juan Tu, Pui Yan Ho, Neelu Batra, Michelle M.L. Tran, Jing-Xin Qiu, Theodore Wun, Primo N. Lara, Xiang Hu, Ai-Xi Yu, Ai-Ming Yu
Theranostics 2021; 11(10): 4858-4871. doi:10.7150/thno.56596
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response
Jin-yu Bai, Ya Li, Guan-hua Xue, Ke-ran Li, Yu-Fan Zheng, Zhi-qing Zhang, Qin Jiang, Yuan-yuan Liu, Xiao-zhong Zhou, Cong Cao
Theranostics 2021; 11(10): 4894-4909. doi:10.7150/thno.56383
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2
Xiaohong Xiang, Yunong Fu, Kun Zhao, Runchen Miao, Xing Zhang, Xiaohua Ma, Chang Liu, Nu Zhang, Kai Qu
Theranostics 2021; 11(10): 4929-4944. doi:10.7150/thno.55672
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Candida albicans disorder is associated with gastric carcinogenesis
Mengya Zhong, Yubo Xiong, Jiabao Zhao, Zhi Gao, Jingsong Ma, Zhengxin Wu, Yongxi Song, Xuehui Hong
Theranostics 2021; 11(10): 4945-4956. doi:10.7150/thno.55209
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Single-cell transcriptome analysis of the heterogeneous effects of differential expression of tumor PD-L1 on responding TCR-T cells
Renpeng Ding, Shang Liu, Shanshan Wang, Huanyi Chen, Fei Wang, Qumiao Xu, Linnan Zhu, Xuan Dong, Ying Gu, Xiuqing Zhang, Cheng-Chi Chao, Qianqian Gao
Theranostics 2021; 11(10): 4957-4974. doi:10.7150/thno.55075
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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FOSL2 promotes VEGF-independent angiogenesis by transcriptionnally activating Wnt5a in breast cancer-associated fibroblasts
Xueying Wan, Shengdong Guan, Yixuan Hou, Yilu Qin, Huan Zeng, Liping Yang, Yina Qiao, Shuiqing Liu, Qiao Li, Ting Jin, Yuxiang Qiu, Manran Liu
Theranostics 2021; 11(10): 4975-4991. doi:10.7150/thno.55074
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly
Jun-Jie Wang, Yu Tian, Ming-Hao Li, Yan-Qin Feng, Li Kong, Fa-Li Zhang, Wei Shen
Theranostics 2021; 11(10): 4992-5009. doi:10.7150/thno.55006
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis
Mei Wang, Yanwen Xu, Yuncong Zhang, Yuhan Chen, Gang Chang, Geng An, Xinyan Yang, Caihong Zheng, Jiexiang Zhao, Zhaoting Liu, Dazhuang Wang, Kai Miao, Shuan Rao, Meng Dai, Dong Wang, Xiao-Yang Zhao
Theranostics 2021; 11(10): 5010-5027. doi:10.7150/thno.55645
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Distinct placental molecular processes associated with early-onset and late-onset preeclampsia
Zhonglu Ren, Yunfei Gao, Yue Gao, Guanmei Liang, Qian Chen, Sijia Jiang, Xiaoxue Yang, Cuixia Fan, Haizhen Wang, Jing Wang, Yi-Wu Shi, Chaoqun Xiao, Mei Zhong, Xinping Yang
Theranostics 2021; 11(10): 5028-5044. doi:10.7150/thno.56141
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells
Jingchun Wang, Huakan Zhao, Lu Zheng, Yu Zhou, Lei Wu, Yanquan Xu, Xiao Zhang, Guifang Yan, Halei Sheng, Rong Xin, Lu Jiang, Juan Lei, Jiangang Zhang, Yu Chen, Jin Peng, Qian Chen, Shuai Yang, Kun Yu, Dingshan Li, Qichao Xie, Yongsheng Li
Theranostics 2021; 11(10): 5045-5060. doi:10.7150/thno.56369
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients
Run Shi, Xuanwen Bao, Kristian Unger, Jing Sun, Shun Lu, Farkhad Manapov, Xuanbin Wang, Claus Belka, Minglun Li
Theranostics 2021; 11(10): 5061-5076. doi:10.7150/thno.56202
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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MLKL: Functions beyond serving as the Executioner of Necroptosis
Chaoning Zhan, Minchun Huang, Xiaojun Yang, Jin Hou
Theranostics 2021; 11(10): 4759-4769. doi:10.7150/thno.54072
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The double-edged roles of ROS in cancer prevention and therapy
Yawei Wang, Huan Qi, Yu Liu, Chao Duan, Xiaolong Liu, Tian Xia, Di Chen, Hai-long Piao, Hong-Xu Liu
Theranostics 2021; 11(10): 4839-4857. doi:10.7150/thno.56747
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Recent progress of surface-enhanced Raman spectroscopy for subcellular compartment analysis
Yanting Shen, Jing Yue, Weiqing Xu, Shuping Xu
Theranostics 2021; 11(10): 4872-4893. doi:10.7150/thno.56409
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria
Yuan Liu, Ziwen Tong, Jingru Shi, Ruichao Li, Mathew Upton, Zhiqiang Wang
Theranostics 2021; 11(10): 4910-4928. doi:10.7150/thno.56205
[Abstract] [Full text] [PDF] [PubMed] [PMC]