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Volume 14 (9); 2024

Research Papers

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PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity Zu Ye, Chee Ping Ng, Haidong Liu, Qimei Bao, Shengfeng Xu, Dan Zu, Yanhua He, Yixing Huang, Abdul Qader Omer Al-Aidaroos, Ke Guo, Jie Li, Lai Ping Yaw, Qiancheng Xiong, Min Thura, Weihui Zheng, Fenghui Guan, Xiangdong Cheng, Yin Shi, Qi Zeng Theranostics 2024; 14(9): 3423-3438. doi:10.7150/thno.93127 Full text PDF PubMed PMC

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Developing targeted therapies for neuroblastoma by dissecting the effects of metabolic reprogramming on tumor microenvironments and progression Wenyi Jin, Yubiao Zhang, Zhijie Zhao, Mingyong Gao Theranostics 2024; 14(9): 3439-3469. doi:10.7150/thno.93962 Full text PDF PubMed PMC

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GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma Yu Zhou, Huakan Zhao, Ran Ren, Mingyue Zhou, Jiangang Zhang, Zhijuan Wu, Yu Chen, Juan Lei, Yang Chen, Ying Yu, Yongsheng Li Theranostics 2024; 14(9): 3470-3485. doi:10.7150/thno.92646 Full text PDF PubMed PMC

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Deciphering m6A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy Jiawen Li, Li Wei, Kaifeng Hu, Yunxiang He, Guidong Gong, Qisong Liu, Yue Zhang, Kaiyu Zhou, Junling Guo, Yimin Hua, Jun Tang, Yifei Li Theranostics 2024; 14(9): 3486-3508. doi:10.7150/thno.95664 Full text PDF PubMed PMC

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Targeting endothelial glycolytic reprogramming by tsRNA-1599 for ocular anti-angiogenesis therapy Xiao-yan Han, Ling-jie Kong, Duo Li, Ming Tong, Xiu-miao Li, Chen Zhao, Qin Jiang, Biao Yan Theranostics 2024; 14(9): 3509-3525. doi:10.7150/thno.96946 Full text PDF PubMed PMC

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Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinoma Yao Li, Fengwei Li, Lei Xu, Xiaodong Shi, Hui Xue, Jianwei Liu, Shilei Bai, Yeye Wu, Zhao Yang, Feng Xue, Yong Xia, Hui Dong, Feng Shen, Kui Wang Theranostics 2024; 14(9): 3526-3547. doi:10.7150/thno.95971 Full text PDF PubMed PMC

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A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy Zhiyong Shi, Miaomiao Liu, Xiaowen Zhang, Jingyang Wang, Junwei Zhang, Zeyan Peng, Li Meng, Ruijing Wang, Lihong Guo, Qiang Zhang, Jing Li, Liang Yang, Jie Liu, Yang Xu, Jie Yan, Jianlin Cui, Shan Ren, Yang Gao, Yanming Wang, Zhi Qi Theranostics 2024; 14(9): 3565-3582. doi:10.7150/thno.92119 Full text PDF PubMed PMC

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Extracellular vesicles from apoptotic BMSCs ameliorate osteoporosis via transporting regenerative signals Maojiao Li, Qi Tang, Chengcheng Liao, Zhuo Wang, Siyuan Zhang, Qingqing Liang, Cheng Liang, Xiaodong Liu, Jingyi Zhang, Weidong Tian, Li Liao Theranostics 2024; 14(9): 3583-3602. doi:10.7150/thno.96174 Full text PDF PubMed PMC

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Highlighting fibroblast plasticity in lung fibrosis: the WI-38 cell line as a model for investigating the myofibroblast and lipofibroblast switch Esmeralda Vásquez-Pacheco, Manuela Marega, Arun Lingampally, Julien Fassy, Marin Truchi, Kerstin Goth, Lisa Trygub, Sara Taghizadeh, Marek Bartkuhn, Ioannis Alexopoulos, Ying Dong, Kevin Lebrigand, Andreas Gunther, Chengshui Chen, JinSan Zhang, Cho-Ming Chao, Denise Al Alam, Elie El Agha, Bernard Mari, Saverio Bellusci, Stefano Rivetti Theranostics 2024; 14(9): 3603-3622. doi:10.7150/thno.93519 Full text PDF PubMed PMC

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PSMA-PET follow-up to assess response in patients not receiving PSMA therapy: Is there value beyond localization of disease? Alina T. Küper, David Kersting, Tugce Telli, Ken Herrmann, Axel Rominger, Ali Afshar-Oromieh, Leonor Lopes, Sofia Karkampouna, Kuangyu Shi, Moon Kim, Boris Hadaschik, Christopher Darr, Lale Umutlu, Wolfgang P. Fendler, Robert Seifert Theranostics 2024; 14(9): 3623-3633. doi:10.7150/thno.96738 Full text PDF PubMed PMC

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Modularized supramolecular assemblies for hypoxia-activatable fluorescent visualization and image-guided theranostics Wen Liu, Bincheng Wang, Bei Guo, Junbin Zhu, Zejun Xu, Jiayue Xu, Zhen Wang, Guodong Sun, Wei Wang, Yi Zhang, Wei Xue Theranostics 2024; 14(9): 3634-3652. doi:10.7150/thno.95590 Full text PDF PubMed PMC

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Chronic stress dysregulates the Hippo/YAP/14-3-3η pathway and induces mitochondrial damage in basolateral amygdala in a mouse model of depression Yan Zhao, Yulong Chen, Chihua Guo, Pingping Li, Zhao Cheng, Lei Zheng, Baoyong Sha, Hao Xu, Xingli Su, Yunpeng Wang Theranostics 2024; 14(9): 3653-3673. doi:10.7150/thno.92676 Full text PDF PubMed PMC

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Towards effective CAIX-targeted radionuclide and checkpoint inhibition combination therapy for advanced clear cell renal cell carcinoma Simone C. Kleinendorst, Egbert Oosterwijk, Janneke Molkenboer-Kuenen, Cathelijne Frielink, Gerben M. Franssen, Daan F. Boreel, Giulia Tamborino, Manon Gloudemans, Merel Hendrikx, Dennis Kroon, Jopp Hillen, Johan Bussink, Stijn Muselaers, Peter Mulders, Mark W. Konijnenberg, Michael P. Wheatcroft, Kwame Twumasi-Boateng, Sandra Heskamp Theranostics 2024; 14(9): 3693-3707. doi:10.7150/thno.96944 Full text PDF PubMed PMC

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Enhancing precision: A predictive model for 177Lu-DOTATATE treatment response in neuroendocrine tumors using quantitative 68Ga-DOTATATE PET and clinicopathological biomarkers Azadeh Akhavanallaf, Sonal Joshi, Arathi Mohan, Francis P Worden, John C Krauss, Habib Zaidi, Kirk Frey, Krithika Suresh, Yuni K Dewaraja, Ka Kit Wong Theranostics 2024; 14(9): 3708-3718. doi:10.7150/thno.98053 Full text PDF PubMed PMC

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FUNDC1 alleviates doxorubicin-induced cardiotoxicity by restoring mitochondrial-endoplasmic reticulum contacts and blocked autophagic flux Weibin He, Zhongchan Sun, Guang Tong, Lin Zeng, Wenlong He, Xiaopan Chen, Cien Zhen, Pengyuan Chen, Ning Tan, Pengcheng He Theranostics 2024; 14(9): 3719-3738. doi:10.7150/thno.92771 Full text PDF PubMed PMC

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An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation Hang Zhou, Zhongyuan He, Youde Cao, Lei Chu, Bing Liang, Kexiao Yu, Zhongliang Deng Theranostics 2024; 14(9): 3739-3759. doi:10.7150/thno.97412 Full text PDF PubMed PMC

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Sleep deprivation causes gut dysbiosis impacting on systemic metabolomics leading to premature ovarian insufficiency in adolescent mice Jiamao Yan, Xiaoyuan Zhang, Kexin Zhu, Mubin Yu, Qingchun Liu, Massimo De Felici, Teng Zhang, Junjie Wang, Wei Shen Theranostics 2024; 14(9): 3760-3776. doi:10.7150/thno.95197 Full text PDF PubMed PMC

Reviews

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Theranostic digital twins: Concept, framework and roadmap towards personalized radiopharmaceutical therapies Hamid Abdollahi, Fereshteh Yousefirizi, Isaac Shiri, Julia Brosch-Lenz, Elahe Mollaheydar, Ali Fele-Paranj, Kuangyu Shi, Habib Zaidi, Ian Alberts, Madjid Soltani, Carlos Uribe, Babak Saboury, Arman Rahmim Theranostics 2024; 14(9): 3404-3422. doi:10.7150/thno.93973 Full text PDF PubMed PMC

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Metronomic chemotherapy in cancer treatment: new wine in an old bottle Huai-liang Wu, Han-xing Zhou, Li-min Chen, Shu-sen Wang Theranostics 2024; 14(9): 3548-3564. doi:10.7150/thno.95619 Full text PDF PubMed PMC

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Trop2-targeted therapies in solid tumors: advances and future directions Xinlin Liu, Leina Ma, Jiyixuan Li, Li Sun, Ying Yang, Ting Liu, Dongming Xing, Saisai Yan, Miao Zhang Theranostics 2024; 14(9): 3674-3692. doi:10.7150/thno.98178 Full text PDF PubMed PMC

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